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Literature summary for 3.2.1.96 extracted from

  • Li, B.; Takegawa, K.; Suzuki, T.; Yamamoto, K.; Wang, L.X.
    Synthesis and inhibitory activity of oligosaccharide thiazolines as a class of mechanism-based inhibitors for endo-beta-N-acetylglucosaminidases (2008), Bioorg. Med. Chem., 15, 4670-4675.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.96

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibitory up to 0.1 mM: O-(beta-D-mannopyranosyl)-(1,4)-(1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline, O-(alpha-D-Mannopyranosyl)-(1,6)-[(alpha-D-mannopyranosyl)-(1,3)]-beta-D-mannopyranosyl-(1,4)-(1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline Flavobacterium sp.
O-(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,6)-[(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,3)]-2,4-di-O-acetyl-beta-D-mannopyranosyl-(1,4)-(3,6-di-O-acetyl-1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline 75% inhibition at 0.001 mM Flavobacterium sp.
O-(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,6)-[(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,3)]-2,4-di-O-acetyl-beta-D-mannopyranosyl-(1,4)-(3,6-di-O-acetyl-1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
-
 Glutamicibacter protophormiae
O-(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,6)-[(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,3)]-2,4-di-O-acetyl-beta-D-mannopyranosyl-(1,4)-(3,6-di-O-acetyl-1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
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 Homo sapiens
O-(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,6)-[(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,3)]-2,4-di-O-acetyl-beta-D-mannopyranosyl-(1,4)-(3,6-di-O-acetyl-1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
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 Mucor hiemalis
O-(alpha-D-mannopyranosyl)-(1,6)-[(alpha-D-mannopyranosyl)-(1,3)]-beta-D-mannopyranosyl-(1,4)-(1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
-
 Glutamicibacter protophormiae
O-(alpha-D-mannopyranosyl)-(1,6)-[(alpha-D-mannopyranosyl)-(1,3)]-beta-D-mannopyranosyl-(1,4)-(1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
-
 Mucor hiemalis
O-(beta-D-mannopyranosyl)-(1,4)-(1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
-
 Glutamicibacter protophormiae
O-(beta-D-mannopyranosyl)-(1,4)-(1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
-
 Mucor hiemalis

Organism

Organism UniProt Comment Textmining
Flavobacterium sp.
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Glutamicibacter protophormiae
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Homo sapiens
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Mucor hiemalis
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IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00022
-
 pH 6.5, 30°C Glutamicibacter protophormiae O-(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,6)-[(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,3)]-2,4-di-O-acetyl-beta-D-mannopyranosyl-(1,4)-(3,6-di-O-acetyl-1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
0.00042
-
 pH 6.5, 30°C Homo sapiens O-(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,6)-[(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,3)]-2,4-di-O-acetyl-beta-D-mannopyranosyl-(1,4)-(3,6-di-O-acetyl-1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
0.006
-
 pH 6.5, 30°C Mucor hiemalis O-(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,6)-[(2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl)-(1,3)]-2,4-di-O-acetyl-beta-D-mannopyranosyl-(1,4)-(3,6-di-O-acetyl-1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
0.013
-
 pH 6.5, 30°C Glutamicibacter protophormiae O-(alpha-D-mannopyranosyl)-(1,6)-[(alpha-D-mannopyranosyl)-(1,3)]-beta-D-mannopyranosyl-(1,4)-(1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
0.038
-
 pH 6.5, 30°C Glutamicibacter protophormiae O-(beta-D-mannopyranosyl)-(1,4)-(1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
0.064
-
 pH 6.5, 30°C Mucor hiemalis O-(alpha-D-mannopyranosyl)-(1,6)-[(alpha-D-mannopyranosyl)-(1,3)]-beta-D-mannopyranosyl-(1,4)-(1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline
0.08
-
 pH 6.5, 30°C Mucor hiemalis O-(beta-D-mannopyranosyl)-(1,4)-(1,2-dideoxy-alpha-D-glucopyrano)-[2,1-d]-2-thiazoline