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Literature summary for 3.2.1.76 extracted from

  • Ou, L.; Herzog, T.L.; Wilmot, C.M.; Whitley, C.B.
    Standardization of alpha-L-iduronidase enzyme assay with Michaelis-Menten kinetics (2014), Mol. Genet. Metab., 111, 113-115.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.76

Protein Variants

Protein Variants Comment Organism
additional information construction of knockout mice from C57BL/6 parents Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Michaelis-Menten kinetics Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 gene IDUA
-
Mus musculus C57BL/6
-
 gene IDUA
-

Source Tissue

Source Tissue Comment Organism Textmining
liver heterozygous mice Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000005 0.00011 activity levels from the same specimens of heterozygous mice vary greatly with different substrate concentrations of 4-methylumbelliferyl-alpha-L-iduronide, comparison of activities in livers at 15 different concentrations, overview. pH and temperature not specified in the publication Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-alpha-L-iduronide + H2O
-
 Mus musculus 4-methylumbelliferol + alpha-L-iduronic acid
-
 ?
4-methylumbelliferyl-alpha-L-iduronide + H2O
-
 Mus musculus C57BL/6 4-methylumbelliferol + alpha-L-iduronic acid
-
 ?

Synonyms

Synonyms Comment Organism
alpha-L-iduronidase
-
 Mus musculus
IDUA
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22 37 assay at Mus musculus