Literature summary for 3.2.1.76 extracted from

Lu, F.; Lico, L.; Hung, S.
Synthesis of a fluorogenic substrate for alpha-L-iduronidase (2012), Arkivoc, 2013, 13-21.

No PubMed abstract available

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylcoumarin-7-yl-alpha-L-iduronic acid + H2O	design and development of an improved and less expensive synthesis method for the fluorogenic substrate, overview. The method is based on the double ketal fixation of the 1,2 and 3,5-hydroxy groups of D-glucose to form a cis-anti-cis-fused tricyclic D-glucofuranosyl derivative, which could undergo elimination to form a 5-exo-double bond followed by electrophilic addition, a Mitsunobu-type glycosylation reaction is used for the coupling of the hemiacetal with the acceptor	Homo sapiens	4-methylcoumarin + alpha-L-iduronic acid	-	?

Synonyms

Synonyms	Comment	Organism
alpha-L-iduronidase	-	Homo sapiens
IDUA	-	Homo sapiens

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Release 2023.1 (January 2023)