Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-fluoro-alpha-L-idopyranosyluronic acid fluoride | reversible, competitive with 4-nitrophenyl-alpha-L-idopyranosiduronate, activity drops down immediately after inhibitor is added | Homo sapiens | |
5-fluoro-alpha-L-idopyranosyluronic acid fluoride | reversible, competitive with 4-methylumbelliferyl-alpha-L-iduronide, activity drops down immediately after inhibitor is added | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | - |
4-methylumbelliferyl-alpha-L-iduronide | pH 4.5, 37°C | Homo sapiens | |
0.53 | - |
4-nitrophenyl-alpha-L-idopyranosiduronate | pH 4.5, 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | cleaves alpha-L-iduronic acid from the nonreducing ends of dermatan sulfate, heparin, and heparan sulfate, deficiency in alpha-L-iduronidase causes mucopolysaccharidosis type I | ? | - |
? |
Organic Solvent | Comment | Organism |
---|---|---|
Methanol | quite stable towards molar concentrations of methanol | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl-alpha-L-iduronide + H2O | - |
Homo sapiens | 4-methylumbelliferone + alpha-L-iduronic acid | - |
? | |
4-methylumbelliferyl-alpha-L-iduronide + methanol | methanolysis | Homo sapiens | ? | - |
? | |
4-nitrophenyl-alpha-L-idopyranosiduronate + H2O | - |
Homo sapiens | 4-nitrophenol + alpha-L-iduronic acid | - |
? | |
5-fluoro-alpha-L-idopyranosyluronic acid fluoride + H2O | - |
Homo sapiens | fluoride + ? | - |
? | |
additional information | cleaves alpha-L-iduronic acid from the nonreducing ends of dermatan sulfate, heparin, and heparan sulfate, deficiency in alpha-L-iduronidase causes mucopolysaccharidosis type I | Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.83 | - |
5-fluoro-alpha-L-idopyranosyluronic acid fluoride | pH 4.5, 37°C | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0012 | - |
5-fluoro-alpha-L-idopyranosyluronic acid fluoride | pH 4.5, 37°C | Homo sapiens | |
0.0046 | - |
2-fluoro-alpha-L-idopyranosyluronic acid fluoride | pH 4.5, 37°C | Homo sapiens |