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Literature summary for 3.2.1.51 extracted from
- Divergent modes of glycan recognition by a new family of carbohydrate-binding modules (2008), J. Biol. Chem., 283, 12604-12613.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | quality of semen is affected in part by the loss in the activity of alpha-fucosidase, which may be useful in early diagnosis of the loss in reproductive capacity during the course of trypanosomiasis and fertility tests | Trypanosoma congolense |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | time-associated loss in the activity of alpha-fucosidase post infection. Sialic acid release is correlated with a gradual loss in activity of the enzyme | Trypanosoma congolense |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00325 | - |
4-methylumbelliferyl-beta-fucoside | control semen | Trypanosoma congolense |  |
| 0.01825 | - |
4-methylumbelliferyl-beta-fucoside | infected semen | Trypanosoma congolense | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma congolense | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially purified | Trypanosoma congolense |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| semen | - |
Trypanosoma congolense | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl-beta-fucoside | - |
Trypanosoma congolense | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | - |
- |
Trypanosoma congolense |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
alpha-fucosidase from the uninfected semen displays a broad acidic pH range of 4.55.5 and a subsequent neutral optimum of pH 6.87.2. There is an absence of the neutral pH optimum for the pathological semen | Trypanosoma congolense |
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Release 2023.1 (January 2023)
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