Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is inducible in patients peripheral blood mononuclear cells by HIV-1 provirus-inducing agent, overview | Homo sapiens | |
Trypsin | the enzyme needs to be proteolytically activated, activation of the enzyme by trypsin | Human immunodeficiency virus 1 |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.27 | - |
serum vitamin D3-binding protein | pH 6.1, 37°C | Homo sapiens | |
1.27 | - |
p-nitrophenyl N-acetyl-alpha-D-galactosaminide | enzyme from HIV patient serum, at pH 6.1 | Homo sapiens | |
4.83 | - |
serum vitamin D3-binding protein | pH 4.3, 37°C | Human immunodeficiency virus 1 | |
4.83 | - |
p-nitrophenyl N-acetyl-alpha-D-galactosaminide | constitutive lung enzyme, at pH 4.3 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Human immunodeficiency virus 1 | the enzyme plays a dual role in regulating both infectivity and immunosuppression | ? | - |
? | |
serum vitamin D3-binding protein + H2O | Human immunodeficiency virus 1 | i.e. Gc protein, the human substrate is the precursor of the principal macrophage activating factor, MAF, the deglycosylated prrecursor cannot be converted, which leads to immunosuppression | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Human immunodeficiency virus 1 | - |
i.e. HIV-1, constitutive enzyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | inducible enzyme | Homo sapiens | - |
lung | - |
Homo sapiens | - |
mononuclear cell | peripheral blood, inducible enzyme | Homo sapiens | - |
serum | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
additional information | - |
- |
Human immunodeficiency virus 1 |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme plays a dual role in regulating both infectivity and immunosuppression | Human immunodeficiency virus 1 | ? | - |
? | |
additional information | the HIV-1 viral envelope glycoprotein gp160 shows alpha-N-galactosaminidase activity | Human immunodeficiency virus 1 | ? | - |
? | |
p-nitrophenyl N-acetyl-alpha-D-galactosaminide + H2O | - |
Homo sapiens | p-nitrophenol + N-acetyl-D-galactosamine | - |
? | |
serum vitamin D3-binding protein + H2O | i.e. Gc protein, the human substrate is the precursor of the principal macrophage activating factor, MAF, the deglycosylated prrecursor cannot be converted, which leads to immunosuppression | Human immunodeficiency virus 1 | ? | - |
? | |
serum vitamin D3-binding protein + H2O | i.e. Gc protein, human substrate, deglycosylation of the substrate | Homo sapiens | ? | - |
? | |
serum vitamin D3-binding protein + H2O | i.e. Gc protein, human substrate, deglycosylation of the substrate | Human immunodeficiency virus 1 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
envelope glycoprotein gp160 | - |
Homo sapiens |
envelope glycoprotein gp160 | - |
Human immunodeficiency virus 1 |
NaGalase | - |
Homo sapiens |
NaGalase | - |
Human immunodeficiency virus 1 |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Human immunodeficiency virus 1 |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.3 | - |
- |
Human immunodeficiency virus 1 |
4.3 | - |
constitutive lung enzyme | Homo sapiens |
6.1 | - |
- |
Homo sapiens |
6.1 | - |
enzyme from HIV patient serum | Homo sapiens |