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Literature summary for 3.2.1.48 extracted from

  • Gu, N.; Adachi, T.; Takeda, J.; Aoki, N.; Tsujimoto, G.; Ishihara, A.; Tsuda, K.; Yasuda, K.
    Sucrase-isomaltase gene expression is inhibited by mutant hepatocyte nuclear factor (HNF)-1alpha and mutant HNF-1beta in Caco-2 cells (2006), J. Nutr. Sci. Vitaminol., 52, 105-112.
    View publication on PubMed
Search for more literature for 3.2.1.48

Activating Compound

Activating Compound Comment Organism Structure
additional information transcription factors HNF-1alpha and HNF-1beta induce constitutive enzyme expression by direct binding to sites SIF2 and SIF3 of the SI gene promoter Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of transcription factors HNF-1alpha and HNF-1beta mutants HNF-1lphaT539fsdelC and HNF-1betaR177X in Caco-2 cells reduces the sucrase-isomaltase activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme expression is transactivated by transcription factors hepatocyte nuclear factors 1alpha and 1beta, HNF-1alpha and HNF-1beta, molecular mechanism and responsible amino acids of HNFs, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
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 Homo sapiens
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small intestine
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme expression is transactivated by transcription factors hepatocyte nuclear factors 1alpha and 1beta, HNF-1alpha and HNF-1beta, molecular mechanism and responsible amino acids of HNFs, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
SI
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 Homo sapiens
sucrase-isomaltase
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 Homo sapiens