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Literature summary for 3.2.1.48 extracted from
- Inhibition of purified human sucrase and isomaltase by ethanolamine derivatives (1996), Biol. Pharm. Bull., 19, 341-344.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | sucrase-isomaltase SI is a marker enzyme of the absorptive villose cells in adult small intestine, human intestinal sucrase-isomaltase help develop a specific inhibitor of sucrase, to retard the absorption of sucrose in the intestinal tract of diabetic patients | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Amino-2-ethyl-1,3-propanediol | - |
Homo sapiens |  |
| 2-amino-2-methyl-1,3-propanediol | - |
Homo sapiens | |
| 2-amino-2-methyl-1-propanol | - |
Homo sapiens | |
| Bis-Tris | - |
Homo sapiens | |
| diethanolamine | - |
Homo sapiens | |
| Monoethanolamine | - |
Homo sapiens | |
| triethanolamine | - |
Homo sapiens | |
| Tris | concentration-dependent biphasic effect, first causing activation, fully competitive inhibition above pH 6.8, inhibition is stronger at alkaline pH values | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 130000 | - |
gel filtration, density gradient, equilibrium centrifugation, sucrase subunit | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| maltose + H2O | Homo sapiens | - |
2 glucose | - |
? | |
| sucrose + H2O | Homo sapiens | - |
D-glucose + D-fructose | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.32 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| maltose + H2O | - |
Homo sapiens | 2 glucose | - |
? | |
| sucrose + H2O | - |
Homo sapiens | D-glucose + D-fructose | - |
? | |
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