Application | Comment | Organism |
---|---|---|
medicine | diagnosis of Krabbe disease | Mus musculus |
medicine | diagnosis of Krabbe disease | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in lentiviral GALC vectors | Homo sapiens |
exression in lentiviral GALC vectors | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.47 | - |
4-methylumbelliferyl-beta-D-galactopyranoside | - |
Mus musculus | |
0.47 | - |
4-methylumbelliferyl-beta-D-galactopyranoside | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
lysosome | - |
Homo sapiens | 5764 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
640000 | - |
gel filtration chromatography | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
twi +/i C57BL6 mice and wild-type mice | - |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
hematopoietic stem cell | - |
Mus musculus | - |
lymphocyte | - |
Homo sapiens | - |
neural stem cell | precursor cell | Mus musculus | - |
neural stem cell | precursor cell | Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
0.14 mU/mg, from Krabbe fibroblasts | Homo sapiens |
additional information | - |
0.31 mU/mg | Mus musculus |
additional information | - |
0.31 mU/mg | Homo sapiens |
additional information | - |
0.6 mU/mg for hematopoetic stem cells, after transduction with lentiviral GALC vector | Mus musculus |
additional information | - |
0.65 mU/mg for hematopoetic stem cells from wild-type mice | Mus musculus |
additional information | - |
0.884 mU/mg, from Krabbe lymphocytes | Homo sapiens |
additional information | - |
1.65 mU/mg, neural presursor cells, after transduction with lentiviral GALC vectors | Homo sapiens |
additional information | - |
2.33 mU/mg for neural precursor cells, after transduction with lentiviral GALC vector | Mus musculus |
additional information | - |
3.2 mU/mg, monocytic U937 cells, after transduction with lentiviral GALC vector | Homo sapiens |
additional information | - |
4.32 mU/mg, from healthy fibroblasts | Homo sapiens |
additional information | - |
5.24 mU/mg, from healthy lymphocytes | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl-beta-D-galactopyranoside + H2O | pH 4.0, 30 min, 37°C | Mus musculus | 4-methylumbelliferone + beta-D-galactopyranose | - |
? | |
4-methylumbelliferyl-beta-D-galactopyranoside + H2O | pH 4.0, 30 min, 37°C | Homo sapiens | 4-methylumbelliferone + beta-D-galactopyranose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-galactocerebrosidase | - |
Mus musculus |
beta-galactocerebrosidase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
pH 4.0 | Mus musculus |
37 | - |
pH 4.0 | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4 | - |
37°C | Mus musculus |
4 | - |
37°C | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
2.5 | 5.5 | - |
Mus musculus |
2.5 | 5.5 | - |
Homo sapiens |