Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.46 extracted from

  • Martino, S.; Tiribuzi, R.; Tortori, A.; Conti, D.; Visigalli, I.; Lattanzi, A.; Biffi, A.; Gritti, A.; Orlacchio, A.
    Specific determination of beta-galactocerebrosidase activity via competitive inhibition of beta-galactosidase (2009), Clin. Chem., 55, 541-548.
    View publication on PubMed

Application

Application Comment Organism
medicine diagnosis of Krabbe disease Mus musculus
medicine diagnosis of Krabbe disease Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in lentiviral GALC vectors Homo sapiens
exression in lentiviral GALC vectors Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.47
-
4-methylumbelliferyl-beta-D-galactopyranoside
-
Mus musculus
0.47
-
4-methylumbelliferyl-beta-D-galactopyranoside
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Mus musculus 5764
-
lysosome
-
Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
640000
-
gel filtration chromatography Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
twi +/i C57BL6 mice and wild-type mice
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-
hematopoietic stem cell
-
Mus musculus
-
lymphocyte
-
Homo sapiens
-
neural stem cell precursor cell Mus musculus
-
neural stem cell precursor cell Homo sapiens
-
U-937 cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
0.14 mU/mg, from Krabbe fibroblasts Homo sapiens
additional information
-
0.31 mU/mg Mus musculus
additional information
-
0.31 mU/mg Homo sapiens
additional information
-
0.6 mU/mg for hematopoetic stem cells, after transduction with lentiviral GALC vector Mus musculus
additional information
-
0.65 mU/mg for hematopoetic stem cells from wild-type mice Mus musculus
additional information
-
0.884 mU/mg, from Krabbe lymphocytes Homo sapiens
additional information
-
1.65 mU/mg, neural presursor cells, after transduction with lentiviral GALC vectors Homo sapiens
additional information
-
2.33 mU/mg for neural precursor cells, after transduction with lentiviral GALC vector Mus musculus
additional information
-
3.2 mU/mg, monocytic U937 cells, after transduction with lentiviral GALC vector Homo sapiens
additional information
-
4.32 mU/mg, from healthy fibroblasts Homo sapiens
additional information
-
5.24 mU/mg, from healthy lymphocytes Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-beta-D-galactopyranoside + H2O pH 4.0, 30 min, 37°C Mus musculus 4-methylumbelliferone + beta-D-galactopyranose
-
?
4-methylumbelliferyl-beta-D-galactopyranoside + H2O pH 4.0, 30 min, 37°C Homo sapiens 4-methylumbelliferone + beta-D-galactopyranose
-
?

Synonyms

Synonyms Comment Organism
beta-galactocerebrosidase
-
Mus musculus
beta-galactocerebrosidase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
pH 4.0 Mus musculus
37
-
pH 4.0 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4
-
37°C Mus musculus
4
-
37°C Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
2.5 5.5
-
Mus musculus
2.5 5.5
-
Homo sapiens