Activating Compound | Comment | Organism | Structure |
---|---|---|---|
(R)-4-(3-phenoxypiperidin-1-yl)-2-(pyridin-3-yl)quinazoline | 50% activation at 0.00365 mM | Homo sapiens | |
(R)-N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00237 mM | Homo sapiens | |
(S)-4-(3-phenoxypiperidin-1-yl)-2-(pyridin-3-yl)quinazoline | 50% activation at 0.00475 mM | Homo sapiens | |
(S)-N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00149 mM | Homo sapiens | |
2-(2-(pyridin-3-yl)quinazolin-4-yl)-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indole | 50% activation at 0.00427 mM | Homo sapiens | |
2-(furan-2-yl)-N-methyl-N-(2-phenoxyethyl)quinazolin-4-amine | 50% activation at 0.02173 mM | Homo sapiens | |
2-(furan-3-yl)-N-methyl-N-(2-phenoxyethyl)quinazolin-4-amine | 50% activation at 0.00168 mM | Homo sapiens | |
4-(2-(pyridin-3-yl)quinazolin-4-yl)-1,4-oxazepane | 50% activation at 0.04414 mM | Homo sapiens | |
4-(2-(pyridin-3-yl)quinazolin-4-yl)-2,3,4,5-tetrahydrobenzo[f ]-[1,4]oxazepine | 50% activation at 0.00974 mM | Homo sapiens | |
4-(2-benzylpiperidin-1-yl)-2-(pyridin-3-yl)quinazoline | 50% activation at 0.0047 mM | Homo sapiens | |
4-(3,4-dihydroisoquinolin-2(1H)-yl)-2-(pyridin-3-yl)quinazoline | 50% activation at 0.00223 mM | Homo sapiens | |
4-(3-benzylpiperidin-1-yl)-2-(pyridin-3-yl)quinazoline | 50% activation at 0.00518 mM | Homo sapiens | |
4-(3-phenoxypyrrolidin-1-yl)-2-(pyridin-3-yl)quinazoline | 50% activation at 0.00117 mM | Homo sapiens | |
4-(3-phenylpiperidin-1-yl)-2-(pyridin-3-yl)quinazoline | 50% activation at 0.00466 mM | Homo sapiens | |
additional information | not activated by N-(cyclopropylmethyl)-N-(2-phenoxyethyl)-2-(pyridin-3-yl)-quinazolin-4-amine, 2-(2-(pyridin-3-yl)quinazolin-4-yl)-2,3,4,5-tetrahydro-1H-pyrido-[4,3-b]indole, N-methyl-N-(2-phenoxyethyl)-2-phenylquinazolin-4-amine, N-methyl-N-(2-phenoxyethyl)-2-(thiophen-3-yl)quinazolin-4-amine, and N-methyl-N-(2-phenoxyethyl)-2-(thiophen-2-yl)quinazolin-4-amine | Homo sapiens | |
N-((1H-benzo[d]imidazol-2-yl)methyl)-N-methyl-2-(pyridin-3-yl)-quinazolin-4-amine | 50% activation at 0.00792 mM | Homo sapiens | |
N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00488 mM | Homo sapiens | |
N-(2-(benzyloxy)ethyl)-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.01687 mM | Homo sapiens | |
N-(2-phenoxyethyl)-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00156 mM | Homo sapiens | |
N-(2-phenoxyethyl)-N-propyl-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00318 mM | Homo sapiens | |
N-(4-ethynylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide | NCGC00188758 | Homo sapiens | |
N-(benzo[c][1,2,5]thiadiazol-5-ylmethyl)-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00184 mM | Homo sapiens | |
N-(benzo[d]oxazol-2-ylmethyl)-N-methyl-2-(pyridin-3-yl)-quinazolin-4-amine | 50% activation at 0.01607 mM | Homo sapiens | |
N-(benzo[d]thiazol-2-ylmethyl)-N-methyl-2-(pyridin-3-yl)-quinazolin-4-amine | 50% activation at 0.0069 mM | Homo sapiens | |
N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-2-(pyridin-3-yl)-quinazolin-4-amine | 50% activation at 0.00163 mM | Homo sapiens | |
N-cyclohexyl-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00236 mM | Homo sapiens | |
N-cyclopentyl-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00636 mM | Homo sapiens | |
N-ethyl-N-(2-phenoxyethyl)-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00538 mM | Homo sapiens | |
N-methyl-2-(pyridin-3-yl)-N-(quinoxalin-2-ylmethyl)quinazolin-4-amine | 50% activation at 0.00163 mM | Homo sapiens | |
N-methyl-N-((2-methylisoindolin-5-yl)methyl)-2-(pyridin-3-yl)-quinazolin-4-amine | 50% activation at 0.01491 mM | Homo sapiens | |
N-methyl-N-(1-phenoxypropan-2-yl)-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00752 mM | Homo sapiens | |
N-methyl-N-(2-phenoxyethyl)-2-(pyridin-2-yl)quinazolin-4-amine | 50% activation at above 0.05 mM | Homo sapiens | |
N-methyl-N-(2-phenoxyethyl)-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00355 mM | Homo sapiens | |
N-methyl-N-(2-phenoxyethyl)-2-(pyridin-4-yl)quinazolin-4-amine | 50% activation at 0.00289 mM | Homo sapiens | |
N-methyl-N-(2-phenoxyethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine | 50% activation at 0.00089 mM | Homo sapiens | |
N-methyl-N-(2-phenoxypropyl)-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00897 mM | Homo sapiens | |
N-methyl-N-(3-phenoxypropyl)-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00616 mM | Homo sapiens | |
N-methyl-N-(3-phenylpropyl)-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00501 mM | Homo sapiens | |
N-methyl-N-(4-phenylbutyl)-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00399 mM | Homo sapiens | |
N-methyl-N-(naphthalen-2-ylmethyl)-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.0038 mM | Homo sapiens | |
N-methyl-N-phenethyl-2-(pyridin-3-yl)quinazolin-4-amine | 50% activation at 0.00139 mM | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-N-methyl-2-(pyridin-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
(S)-N-methyl-2-(pyridin-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)quinazolin-4-amine | - |
Homo sapiens | |
2-(pyridin-3-yl)-N-[(2R)-1,2,3,4-tetrahydronaphthalen-2-yl]quinazolin-4-amine | - |
Homo sapiens | |
2-(pyridin-3-yl)-N-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]quinazolin-4-amine | - |
Homo sapiens | |
N-(1-phenoxypropan-2-yl)-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-(2,3-dihydro-1H-inden-2-yl)-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-(2,3-dihydro-1H-inden-2-yl)-2-(thiophen-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-(2,3-dihydro-1H-inden-2-yl)-N-methyl-2-(pyridin-3-yl)-quinazolin-4-amine | - |
Homo sapiens | |
N-(2-(benzyloxy)ethyl)-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-(2-phenoxypropyl)-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-(2-phenylethyl)-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-(3-phenoxypropyl)-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-(3-phenylpropyl)-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-(4-phenylbutyl)-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-cycloheptyl-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-cycloheptyl-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-cyclohexyl-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-cyclooctyl-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-cyclooctyl-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens | |
N-cyclopentyl-2-(pyridin-3-yl)quinazolin-4-amine | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04062 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl beta-D-glucopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + beta-D-glucopyranose | - |
? | |
5-(pentafluorobenzoylamino)-fluorescein di-beta-D-glucopyranoside + H2O | - |
Homo sapiens | 5-(pentafluorobenzoylamino)-fluorescein + 2 beta-D-glucopyranose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-glucocerebrosidase | - |
Homo sapiens |
GBA1 | - |
Homo sapiens |
Gcase | - |
Homo sapiens |
velaglucerase alfa | commercial preparation | Homo sapiens |
Vpriv | commercial preparation | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000083 | - |
at pH 5.0 and 25°C | Homo sapiens | N-(2,3-dihydro-1H-inden-2-yl)-2-(pyridin-3-yl)quinazolin-4-amine | |
0.0000087 | - |
at pH 5.0 and 25°C | Homo sapiens | 2-(pyridin-3-yl)-N-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]quinazolin-4-amine | |
0.0000099 | - |
at pH 5.0 and 25°C | Homo sapiens | 2-(pyridin-3-yl)-N-[(2R)-1,2,3,4-tetrahydronaphthalen-2-yl]quinazolin-4-amine | |
0.000027 | - |
at pH 5.0 and 25°C | Homo sapiens | N-cyclooctyl-2-(pyridin-3-yl)quinazolin-4-amine | |
0.000042 | - |
at pH 5.0 and 25°C | Homo sapiens | N-cycloheptyl-2-(pyridin-3-yl)quinazolin-4-amine | |
0.000177 | - |
at pH 5.0 and 25°C | Homo sapiens | N-cyclohexyl-2-(pyridin-3-yl)quinazolin-4-amine | |
0.00043 | - |
at pH 5.0 and 25°C | Homo sapiens | (S)-N-methyl-2-(pyridin-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)quinazolin-4-amine | |
0.00072 | - |
at pH 5.0 and 25°C | Homo sapiens | N-cyclopentyl-2-(pyridin-3-yl)quinazolin-4-amine | |
0.00097 | - |
at pH 5.0 and 25°C | Homo sapiens | N-(2-phenylethyl)-2-(pyridin-3-yl)quinazolin-4-amine | |
0.00128 | - |
at pH 5.0 and 25°C | Homo sapiens | N-(4-phenylbutyl)-2-(pyridin-3-yl)quinazolin-4-amine | |
0.00178 | - |
at pH 5.0 and 25°C | Homo sapiens | N-(3-phenylpropyl)-2-(pyridin-3-yl)quinazolin-4-amine | |
0.00188 | - |
at pH 5.0 and 25°C | Homo sapiens | N-(1-phenoxypropan-2-yl)-2-(pyridin-3-yl)quinazolin-4-amine | |
0.00214 | - |
at pH 5.0 and 25°C | Homo sapiens | N-(2,3-dihydro-1H-inden-2-yl)-N-methyl-2-(pyridin-3-yl)-quinazolin-4-amine | |
0.00254 | - |
at pH 5.0 and 25°C | Homo sapiens | N-(3-phenoxypropyl)-2-(pyridin-3-yl)quinazolin-4-amine | |
0.00424 | - |
at pH 5.0 and 25°C | Homo sapiens | N-(2-phenoxypropyl)-2-(pyridin-3-yl)quinazolin-4-amine | |
0.00587 | - |
at pH 5.0 and 25°C | Homo sapiens | (R)-N-methyl-2-(pyridin-3-yl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)quinazolin-4-amine | |
0.0073 | - |
at pH 5.0 and 25°C | Homo sapiens | N-(2-(benzyloxy)ethyl)-2-(pyridin-3-yl)quinazolin-4-amine | |
0.00838 | - |
at pH 5.0 and 25°C | Homo sapiens | N-cyclooctyl-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine | |
0.00994 | - |
at pH 5.0 and 25°C | Homo sapiens | N-cycloheptyl-N-methyl-2-(pyridin-3-yl)quinazolin-4-amine |