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Literature summary for 3.2.1.45 extracted from

  • Walden, C.M.; Sandhoff, R.; Chuang, C.C.; Yildiz, Y.; Butters, T.D.; Dwek, R.A.; Platt, F.M.; van der Spoel, A.C.
    Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis (2007), J. Biol. Chem., 282, 32655-32664.
    View publication on PubMed
Search for more literature for 3.2.1.45

Inhibitors

Inhibitors Comment Organism Structure
N-carboxynonyldeoxynojirimycin
-
 Mus musculus
N-dodecyldeoxynojirimycin
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Mus musculus methylumbelliferone + glucose
-
 ?
glucosylceramide + H2O
-
 Mus musculus beta-D-glucose + ceramide
-
 ?

Synonyms

Synonyms Comment Organism
beta-glucosidase 2
-
 Mus musculus
GBA2
-
 Mus musculus
microsomal bile acid beta-glucosidase
-
 Mus musculus
non-lysosomal glucosylceramidase
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00014
-
-
 Mus musculus N-carboxy-nonyldeoxynojirimycin
0.0229
-
-
 Mus musculus N-dodecyl-deoxynojirimycin