Any feedback?
Literature summary for 3.2.1.45 extracted from
- Glucosylceramidase mass and subcellular localization are modulated by cholesterol in Niemann-Pick disease type C (2004), J. Biol. Chem., 279, 17674-17680.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in fibroblasts of patients with Niemann-Pick disease type C, the cholesterol storage affects the stability of enzyme, decreasing its mass and activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
the difference in activity between the control and the mutated cells correlates well with difference in the enzyme mass | Homo sapiens |
| 0.075 | 0.1 | enzyme in cell lines from two patients with Niemann-Pick disease type C | Homo sapiens |
| 0.4 | - |
enzyme in normal fibroblasts | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
