Any feedback?
Literature summary for 3.2.1.45 extracted from
- Molecular forms, biosynthesis and maturation of glucocerebrosidase, a membrane-associated lysosomal enzyme deficient in Gaucher disease (1986), NATO ASI Ser. A, Life Sci., 116, 735-745.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glycoprotein | heat-stable | Homo sapiens |  |
| sodium taurocholate | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
| membrane | - |
Homo sapiens | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
after deglycosylation, SDS-PAGE | Homo sapiens |
| 59000 | - |
3 forms, 66000 Da and 62500 Da, absent in Gaucher disease patients, gel filtration, SDS-PAGE | Homo sapiens |
| 62500 | - |
3 forms, 66000 Da and 59000 Da, gel filtration, SDS-PAGE | Homo sapiens |
| 66000 | - |
3 forms, 62500 Da and 59000 Da, gel filtration, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glucocerebroside + H2O | Homo sapiens | - |
glucose + ceramide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
overview | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| fibroblast | skin fibroblasts in culture | Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
| urine | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl-beta-D-glucopyranoside + H2O | - |
Homo sapiens | methylumbelliferone + glucose | - |
? | |
| glucocerebroside + H2O | - |
Homo sapiens | glucose + ceramide | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | in tissues: monomer or aggregate, interconvertible | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
