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Literature summary for 3.2.1.40 extracted from

  • Pearson, M.S.; Floquet, N.; Bello, C.; Vogel, P.; Plantier-Royon, R.; Szymoniak, J.; Bertus, P.; Behr, J.B.
    The spirocyclopropyl moiety as a methyl surrogate in the structure of L-fucosidase and L-rhamnosidase inhibitors (2009), Bioorg. Med. Chem., 17, 8020-8026.
    View publication on PubMed
Search for more literature for 3.2.1.40

Inhibitors

Inhibitors Comment Organism Structure
(1R,2S,6R,8S,8aS)-6-methyloctahydroindolizine-1,2,8-triol
-
 Penicillium decumbens
(2S,3S,4S)-2-methyl-3,4-dihydro-2H-pyrrole-3,4-diol
-
 Penicillium decumbens
(2S,3S,4S)-2-methylpyrrolidine-3,4-diol
-
 Penicillium decumbens
(3S,4R)-3,4-dihydroxy-5-spirocyclopropyl-DELTA-pyrroline
-
 Penicillium decumbens
(3S,4S)-3,4-dihydroxy-5-spirocyclopropyl-DELTA-pyrroline 72% inhibition at 1 mM Penicillium decumbens
(6S,7S,8S)-4-azaspiro[2.5]octane-6,7,8-triol 72% inhibition at 1 mM Penicillium decumbens
additional information not inhibited by deoxyrhamnojirimycin and 5-C-spirocyclopropyl-(5-demethyl-1-deoxy)-L-fuconojirimycin Penicillium decumbens
[4-([[(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]methyl]amino)-5-hydroxy-6-methylpyridin-2-yl]methyl dihydrogen phosphate
-
 Penicillium decumbens
[4-([[(2S,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl]amino)-5-hydroxy-6-methylpyridin-2-yl]methyl dihydrogen phosphate
-
 Penicillium decumbens

Organism

Organism UniProt Comment Textmining
Penicillium decumbens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl alpha-L-rhamnoside + H2O
-
 Penicillium decumbens alpha-L-rhamnose + 4-nitrophenol
-
 ?

Synonyms

Synonyms Comment Organism
L-rhamnosidase
-
 Penicillium decumbens
naringinase
-
 Penicillium decumbens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00003
-
 (1R,2S,6R,8S,8aS)-6-methyloctahydroindolizine-1,2,8-triol
-
 Penicillium decumbens
0.00014
-
 (2S,3S,4S)-2-methyl-3,4-dihydro-2H-pyrrole-3,4-diol
-
 Penicillium decumbens
0.003
-
 [4-([[(2S,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl]amino)-5-hydroxy-6-methylpyridin-2-yl]methyl dihydrogen phosphate
-
 Penicillium decumbens
0.0032
-
 [4-([[(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]methyl]amino)-5-hydroxy-6-methylpyridin-2-yl]methyl dihydrogen phosphate
-
 Penicillium decumbens
0.0055
-
 (2S,3S,4S)-2-methylpyrrolidine-3,4-diol
-
 Penicillium decumbens
0.057
-
 (3S,4R)-3,4-dihydroxy-5-spirocyclopropyl-DELTA-pyrroline
-
 Penicillium decumbens