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Literature summary for 3.2.1.40 extracted from

  • Kim, J.H.; Curtis-Long, M.J.; Seo, W.D.; Lee, J.H.; Lee, B.W.; Yoon, Y.J.; Kang, K.Y.; Park, K.H.
    alpha-Rhamnosidase inhibitory activities of polyhydroxylated pyrrolidine (2005), Bioorg. Med. Chem. Lett., 15, 4282-4285.
    View publication on PubMed
Search for more literature for 3.2.1.40

Inhibitors

Inhibitors Comment Organism Structure
(2S,3R,4S)-benzyl-3,4-dihydroxy pyrrolidine IC50 is 0.168 mM Penicillium decumbens
(2S,3R,4S)-deacetyl anisomycin IC50 is 0.137 mM Penicillium decumbens
(2S,3S,4R)-benzyl-3,4-dihydroxy pyrrolidine competitive Penicillium decumbens
(2S,3S,4R)-deacetyl anisomycin competitive Penicillium decumbens
(2S,3S,4S)-anisomycin competitive Penicillium decumbens
(2S,3S,4S)-deacetyl anisomycin competitive Penicillium decumbens
additional information design from aromatic amino acids and inhibitory potency of polyhydroxylated pyrrolidines, stereochemistry, overview Penicillium decumbens

Organism

Organism UniProt Comment Textmining
Penicillium decumbens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl alpha-L-rhamnopyranoside + H2O
-
 Penicillium decumbens 4-nitrophenol + alpha-L-rhamnose
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Penicillium decumbens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7
-
 assay at Penicillium decumbens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0026
-
 (2S,3S,4R)-deacetyl anisomycin pH 6.7, 30°C, versus 4-nitrophenyl alpha-L-rhamnopyranoside Penicillium decumbens
0.0029
-
 (2S,3R,4S)-benzyl-3,4-dihydroxy pyrrolidine pH 6.7, 30°C, versus 4-nitrophenyl alpha-L-rhamnopyranoside Penicillium decumbens
0.0029
-
 (2S,3S,4S)-deacetyl anisomycin pH 6.7, 30°C, versus 4-nitrophenyl alpha-L-rhamnopyranoside Penicillium decumbens
0.058
-
 (2S,3S,4S)-anisomycin pH 6.7, 30°C, versus 4-nitrophenyl alpha-L-rhamnopyranoside Penicillium decumbens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.137
-
 IC50 is 0.137 mM Penicillium decumbens (2S,3R,4S)-deacetyl anisomycin
0.168
-
 IC50 is 0.168 mM Penicillium decumbens (2S,3R,4S)-benzyl-3,4-dihydroxy pyrrolidine