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Literature summary for 3.2.1.35 extracted from

  • Duterme, C.; Mertens-Strijthagen, J.; Tammi, M.; Flamion, B.
    Two novel functions of hyaluronidase-2 (Hyal2) are formation of the glycocalyx and control of CD44-ERM interactions (2009), J. Biol. Chem., 284, 33495-33508.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
-
Rattus norvegicus
dimethyl sulfoxide
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface Hyal2 is partly expressed at the cell surface Rattus norvegicus 9986
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q9Z2Q3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Rat-1/BB16 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hyaluronan + 2 H2O
-
Rattus norvegicus N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
?

Synonyms

Synonyms Comment Organism
Hyal2
-
Rattus norvegicus
hyaluronidase-2
-
Rattus norvegicus

General Information

General Information Comment Organism
physiological function Hyal2, through direct interactions with CD44 and possibly some pericellular hyaluronidase activity requiring acidic foci, suppresses the formation or the stability of the glycocalyx, modulates ezrin-radixin-moesin-related cytoskeletal interactions, and diminishes cell motility Rattus norvegicus