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Literature summary for 3.2.1.35 extracted from

  • Wang, F.; Grigorieva, E.V.; Li, J.; Senchenko, V.N.; Pavlova, T.V.; Anedchenko, E.A.; Kudryavtseva, A.V.; Tsimanis, A.; Angeloni, D.; Lerman, M.I.; Kashuba, V.I.; Klein, G.; Zabarovsky, E.R.
    HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro (2008), PLoS ONE, 3, e3031.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine as major hyaluronidases in human cells, HYAL1 and HYAL2 may control intercellular interactions and microenvironment of tumour cells providing excellent targets for cancer treatment Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens this gene may play an important role in the development of lung and renal malignancies, the expression of hyaluronidase-1 or hyaluronidase-2 suppresses tumour growth in vivo but not in vitro, HYAL2 inhibits experimental lung metastases in nu/nu mice ?
-
?
additional information Homo sapiens this gene may play an important role in the development of lung and renal malignancies, the expression of hyaluronidase-1 suppresses tumour growth in vivo but not in vitro ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q12794 HYAL1 gene of the the LUCA region
-
Homo sapiens Q12891 HYAL2 gene of the the LUCA region
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information this gene may play an important role in the development of lung and renal malignancies, the expression of hyaluronidase-1 or hyaluronidase-2 suppresses tumour growth in vivo but not in vitro, HYAL2 inhibits experimental lung metastases in nu/nu mice Homo sapiens ?
-
?
additional information this gene may play an important role in the development of lung and renal malignancies, the expression of hyaluronidase-1 suppresses tumour growth in vivo but not in vitro Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
hyaluronidase-1
-
Homo sapiens
hyaluronidase-2
-
Homo sapiens
hyaluronoglucosaminidase 1
-
Homo sapiens
hyaluronoglucosaminidase 2
-
Homo sapiens