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Literature summary for 3.2.1.35 extracted from
- Inhibition of Naja naja venom hyaluronidase by plant-derived bioactive components and polysaccharides (2005), Biochemistry (Moscow), 70, 948-952.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | isozyme NNH1 is a target for first aid agents from plants in snakebit therapy | Naja naja |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ajmaline | - |
Naja naja |  |
| aristolochic acid | complete inhibition | Naja naja | |
| butylated hydroxytoluene | - |
Naja naja | |
| chlorogenic acid | - |
Naja naja | |
| Chondroitin sulfates | - |
Naja naja | |
| curcumin | - |
Naja naja | |
| dermatan sulfate | - |
Naja naja | |
| dexamethasone | - |
Naja naja | |
| flavone | - |
Naja naja | |
| heparan sulfate | - |
Naja naja | |
| heparin | - |
Naja naja | |
| indomethacin | - |
Naja naja | |
| additional information | ascorbic acid is a poor inhibitor, the plant-derived inhibitors inhibit isozyme NNH1, reduce the local tissue damage, and retard the easy diffusion of systemic toxins and increase survival time, inhibitory potencies, overview | Naja naja | |
| n-propyl gallate | - |
Naja naja | |
| nordihydroguaiaretic acid | - |
Naja naja | |
| quercetin | complete inhibition | Naja naja | |
| reserpine | - |
Naja naja | |
| Tannic acid | - |
Naja naja | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | venom | Naja naja | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 69000 | - |
1 * 69000, isozyme NNH1, SDS-PAGE | Naja naja |
| 74000 | - |
isozyme NNH1, gel filtration | Naja naja |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Naja naja | - |
isozyme NNH1 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native isozyme NNH1 33fold to homogeneity from venom by successive gel filtration and ion exchange chromatography | Naja naja |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Naja naja | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 69000, isozyme NNH1, SDS-PAGE | Naja naja |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hyaluronidase | - |
Naja naja |
| NNH1 | - |
Naja naja |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Naja naja |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
assay at | Naja naja |
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Release 2023.1 (January 2023)
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