BRENDA - Enzyme Database
show all sequences of 3.2.1.35

Inhibition of hyaluronidase by fully O-sulfonated glycosaminoglycans

Toida, T.; Ogita, Y.; Suzuki, A.; Toyoda, H.; Imanari, T.; Arch. Biochem. Biophys. 370, 176-182 (1999)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
chondroitin O-sulfate
IC50 = 0.00133 mg/ml
Homo sapiens
dermatan O-sulfate
IC50 = 0.00133 mg/ml
Homo sapiens
fully O-sulfonated chondroitin sulfate
competitive and noncompetitive mode, 50% inhibition at 0.00135 mg/ml
Homo sapiens
fully O-sulfonated dermatan sulfate
competitive and noncompetitive mode, 50% inhibition at 0.00133 mg/ml
Homo sapiens
fully O-sulfonated heparan sulfate
competitive and noncompetitive mode, 50% inhibition at 0.00128 mg/ml
Homo sapiens
fully O-sulfonated heparin
50% inhibition at 0.00114 mg/ml
Homo sapiens
fully O-sulfonated hyaluronan
50% inhibition at 0.00078 mg/ml
Homo sapiens
heparan O-sulfate
IC50 = 0.00128 mg/ml
Homo sapiens
heparin
IC50 = 0.00114 mg/ml, non-competitive inhibition; noncompetitive
Homo sapiens
heparin O-sulfate
IC50 = 0.00114 mg/ml, competitive and non-competitive inhibitory effects
Homo sapiens
hyaluronan O-sulfate
IC50 = 0.00078 mg/ml
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
extracellular
-
Homo sapiens
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
hyaluronic acid + H2O
Homo sapiens
involved in inflammatory reactions, exists as inactive form activated by metal ions
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Reaction
Reaction
Commentary
Organism
Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate
also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
urine
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
activity measured as turbidicity reducing units; development of a flow injection assay method using commercial bovine enzyme and fluorometric detection, comparison of fluorogenic reagents, enzyme activity in human urine samples
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
hyaluronan + H2O
-
171393
Homo sapiens
tetraoligosaccharides + hexaoligosaccharides
after complete digestion
171393
Homo sapiens
?
hyaluronan + H2O
from Streptococcus zooepidemicus
171393
Homo sapiens
N-acetyl-beta-D-glucosamine + D-glucuronate
-
171393
Homo sapiens
?
hyaluronic acid + H2O
involved in inflammatory reactions, exists as inactive form activated by metal ions
171393
Homo sapiens
?
-
-
-
-
hyaluronic acid + H2O
-
171393
Homo sapiens
hyaluronic acid oligomers
-
171393
Homo sapiens
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5
-
assay at
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
chondroitin O-sulfate
IC50 = 0.00133 mg/ml
Homo sapiens
dermatan O-sulfate
IC50 = 0.00133 mg/ml
Homo sapiens
fully O-sulfonated chondroitin sulfate
competitive and noncompetitive mode, 50% inhibition at 0.00135 mg/ml
Homo sapiens
fully O-sulfonated dermatan sulfate
competitive and noncompetitive mode, 50% inhibition at 0.00133 mg/ml
Homo sapiens
fully O-sulfonated heparan sulfate
competitive and noncompetitive mode, 50% inhibition at 0.00128 mg/ml
Homo sapiens
fully O-sulfonated heparin
50% inhibition at 0.00114 mg/ml
Homo sapiens
fully O-sulfonated hyaluronan
50% inhibition at 0.00078 mg/ml
Homo sapiens
heparan O-sulfate
IC50 = 0.00128 mg/ml
Homo sapiens
heparin
IC50 = 0.00114 mg/ml, non-competitive inhibition; noncompetitive
Homo sapiens
heparin O-sulfate
IC50 = 0.00114 mg/ml, competitive and non-competitive inhibitory effects
Homo sapiens
hyaluronan O-sulfate
IC50 = 0.00078 mg/ml
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
extracellular
-
Homo sapiens
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
hyaluronic acid + H2O
Homo sapiens
involved in inflammatory reactions, exists as inactive form activated by metal ions
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
urine
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
activity measured as turbidicity reducing units; development of a flow injection assay method using commercial bovine enzyme and fluorometric detection, comparison of fluorogenic reagents, enzyme activity in human urine samples
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
hyaluronan + H2O
-
171393
Homo sapiens
tetraoligosaccharides + hexaoligosaccharides
after complete digestion
171393
Homo sapiens
?
hyaluronan + H2O
from Streptococcus zooepidemicus
171393
Homo sapiens
N-acetyl-beta-D-glucosamine + D-glucuronate
-
171393
Homo sapiens
?
hyaluronic acid + H2O
involved in inflammatory reactions, exists as inactive form activated by metal ions
171393
Homo sapiens
?
-
-
-
-
hyaluronic acid + H2O
-
171393
Homo sapiens
hyaluronic acid oligomers
-
171393
Homo sapiens
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5
-
assay at
Homo sapiens
Other publictions for EC 3.2.1.35
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
749985
Vivas-Ruiz
Biochemical and molecular cha ...
Bothrops atrox
Biochimie
162
33-45
2019
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750247
Fayad
Effect of modified di- and tr ...
Bos taurus
Carbohydr. Res.
475
56-64
2019
1
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751198
Xin
Affinity adsorption of bovine ...
Bos taurus
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
1092
422-431
2018
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751311
Park
Characterization of recombina ...
Bos taurus
J. Microbiol. Biotechnol.
28
1547-1553
2018
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1
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750477
Buhren
Hyaluronidase from clinical a ...
Bos taurus
Eur. J. Med. Res.
21
0000
2016
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1
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751278
Bhavya
-
Low-molecular weight hyaluron ...
Bungarus caeruleus
J. Liq. Chromatogr. Relat. Technol.
39
203-208
2016
6
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3
1
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6
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3
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1
1
1
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1
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749559
Fang
Kinetic investigation of reco ...
Homo sapiens
Anal. Biochem.
480
74-81
2015
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1
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1
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750174
Albeiroti
Platelet hyaluronidase-2 An e ...
Homo sapiens
Blood
125
1460-1469
2015
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2
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751820
Liu
High-resolution hyaluronidase ...
Deinagkistrodon acutus, Gloydius brevicaudus, Naja atra, Trimeresurus stejnegeri
Phytochemistry
119
62-69
2015
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729824
Wang
Two novel functions of hyaluro ...
Streptococcus agalactiae, Streptococcus agalactiae GD201008-001
Infect. Immun.
82
2615-2625
2014
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729859
Goto
C-mannosylation of human hyalu ...
Homo sapiens
Int. J. Oncol.
45
344-350
2014
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730300
Li
-
Isolation and enzymatic charac ...
Bos grunniens
Korean J. Chem. Engin.
31
2027-2034
2014
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1
9
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730676
Horta
Molecular, immunological, and ...
Tityus serrulatus
PLoS Negl. Trop. Dis.
8
e2693
2014
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1
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730951
Jin
High-yield novel leech hyaluro ...
Bos taurus
Sci. Rep.
4
4471
2014
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1
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729118
Liu
-
Inhibition and interaction wit ...
Bos taurus
Asian J. Chem.
25
10262-10266
2013
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4
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729842
Sunitha
Inhibition of hyaluronidase by ...
Apis mellifera, Bos taurus, Echis carinatus, Homo sapiens
Int. J. Biol. Macromol.
55
39-46
2013
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8
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4
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730675
Ferrer
A novel hyaluronidase from bro ...
Loxosceles intermedia
PLoS Negl. Trop. Dis.
7
e2206
2013
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1
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1
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5
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1
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1
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730998
Karasova
Hyaluronidase: its effects on ...
Bos taurus
Toxicol. Lett.
220
167-171
2013
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1
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729332
Bordon
Isolation, enzymatic character ...
Crotalus durissus terrificus
Biochimie
94
2740-2748
2012
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3
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Kakizaki
Effects of divalent cations on ...
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2011
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Hyal2 is a glycosylphosphatidy ...
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2011
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Autodisplay of catalytically a ...
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Bakke
Identification, characterizati ...
Talaromyces purpureogenus
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585
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716966
Madokoro
Properties and cDNA cloning of ...
Synanceia verrucosa
Toxicon
58
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2011
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Kramer
HYAL-1 Hyaluronidase: A Potent ...
Homo sapiens
Eur. Urol.
57
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2010
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Ormiston
The enzymatic degradation of h ...
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Murata
Hyaluronidase inhibitors from ...
Bos taurus
Chem. Pharm. Bull.
58
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2010
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703288
Belem-Goncalves
Hyaluronidase binds differentl ...
Bos taurus
Colloids Surf. B Biointerfaces
75
466-471
2010
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703581
Colombo
Editorial Comment on: HYAL-1 h ...
Homo sapiens
Eur. Urol.
57
93-94
2010
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Iwanaga
Hyaluronidase inhibitors from ...
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Srivastav
Inhibition of hyaluronidase ac ...
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Kakizaki
Mechanism for the hydrolysis o ...
Bos taurus
FEBS J.
277
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2010
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716094
Lenormand
pH effects on the hyaluronan h ...
Bos taurus
Matrix Biol.
29
330-337
2010
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716095
Chatel
The C. elegans hyaluronidase: ...
Caenorhabditis elegans
Matrix Biol.
29
494-502
2010
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716289
Reese
Acidic hyaluronidase activity ...
Mus musculus
Mol. Reprod. Dev.
77
759-772
2010
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3
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4
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1
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716829
Jung
Production of human hyaluronid ...
Homo sapiens
Protein Expr. Purif.
74
181-188
2010
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717012
Olgen
Investigation of aminomethyl i ...
Bos taurus
Z. Naturforsch. C
65
445-450
2010
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Zhang
Hyaluronidase activity of huma ...
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J. Biol. Chem.
284
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2009
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1
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2
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20
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10
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2
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1
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699185
Sharma
Effect of anticoagulants on th ...
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J. Clin. Lab. Anal.
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2009
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1
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1
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2
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1
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1
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1
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1
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-
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701614
de la Motte
Platelet-derived hyaluronidase ...
Homo sapiens, Mus musculus
Am. J. Pathol.
174
2254-2264
2009
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2
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701690
Kim
An operationally simple colori ...
Bos taurus, Homo sapiens
Analyst
134
1291-1293
2009
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2
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1
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1
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1
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1
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1
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-
-
-
-
-
-
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702420
Berdiaki
bFGF induces changes in hyalur ...
Homo sapiens
Biochim. Biophys. Acta
1790
1258-1265
2009
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2
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1
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2
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2
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2
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2
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1
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702526
Kimura
Functional roles of mouse sper ...
Mus musculus
Biol. Reprod.
81
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2009
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1
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2
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1
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2
1
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2
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1
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702753
Barla
Inhibitive effects of alkyl ga ...
Bos taurus
Biosci. Biotechnol. Biochem.
73
2335-2337
2009
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9
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702883
Nykopp
Expression of hyaluronan synth ...
Homo sapiens
BMC Cancer
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143
2009
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703231
Wang
Comparison of hyaluronidase ex ...
Homo sapiens
Chin. Med. Sci.
122
1300-1304
2009
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1
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11
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1
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1
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1
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Narayanan
Hyaluronidase for pharmacologi ...
Ovis aries
Dev. Ophthalmol.
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2009
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1
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1
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704505
Reitinger
Designed human serum hyaluroni ...
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J. Biol. Chem.
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2009
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2
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1
-
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1
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704586
Duterme
Two novel functions of hyaluro ...
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284
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2009
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1
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1
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1
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1
1
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705485
Lenormand
The hyaluronan-protein complex ...
Bos taurus
Matrix Biol.
28
365-372
2009
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-
-
-
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1
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1
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1
-
-
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-
-
-
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-
-
-
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705486
Ruegheimer
Hyaluronan synthases and hyalu ...
Rattus norvegicus
Matrix Biol.
28
390-395
2009
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-
-
-
-
-
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6
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2
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4
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8
-
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4
-
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1
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4
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706691
Evison
Human recombinant hyaluronidas ...
Homo sapiens
Reprod. Biomed. Online
18
811-814
2009
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4
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706880
de Sa
Isoforms of hyaluronidases can ...
Homo sapiens
Urol. Oncol.
27
377-381
2009
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1
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-
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1
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2
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1
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1
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1
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1
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-
1
-
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-
-
-
-
-
-
-
-
-
-
-
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-
680047
Hemming
Mouse Hyal3 encodes a 45-56 kD ...
Mus musculus
Glycobiology
18
280-289
2008
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-
1
-
-
-
-
-
1
-
1
-
-
3
-
1
-
-
-
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2
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1
1
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1
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1
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1
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1
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-
-
2
-
-
-
-
-
-
1
1
-
-
-
-
-
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-
681743
Deschrevel
Hyaluronidase activity is modu ...
Bos taurus
Matrix Biol.
27
242-253
2008
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-
-
-
-
-
-
-
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1
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1
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2
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1
-
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2
-
-
-
-
-
-
-
-
-
-
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-
-
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682687
Reitinger
High-yield recombinant express ...
Apis mellifera, synthetic construct
Protein Expr. Purif.
57
226-233
2008
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2
2
-
2
-
-
-
-
-
-
-
-
2
-
-
2
-
-
3
6
-
10
-
2
2
3
-
2
2
2
-
-
-
-
-
2
2
-
-
2
-
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-
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-
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2
-
3
6
-
10
-
2
2
3
-
2
2
2
-
-
-
-
-
-
-
690383
Monzon
Hyaluronidase expression and a ...
Homo sapiens
Am. J. Respir. Cell Mol. Biol.
39
289-295
2008
2
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1
-
-
-
-
-
3
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-
3
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4
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-
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-
-
3
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6
-
1
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-
1
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-
6
-
3
-
-
-
-
-
-
-
-
6
-
-
3
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-
-
9
-
-
6
-
3
-
-
-
3
-
-
-
-
-
-
-
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-
691856
Ganesh
Intratumoral coadministration ...
Homo sapiens
Clin. Cancer Res.
14
3933-3941
2008
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1
-
-
-
-
-
-
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-
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1
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1
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-
-
-
-
-
-
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-
-
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693055
Kaneiwa
Identification of a novel chon ...
Caenorhabditis elegans, Caenorhabditis elegans N2
J. Biol. Chem.
283
14971-14979
2008
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1
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3
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1
-
-
14
-
-
-
-
-
-
-
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6
-
-
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1
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-
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1
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3
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1
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-
-
-
6
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
694822
Wang
HYAL1 and HYAL2 inhibit tumour ...
Homo sapiens
PLoS ONE
3
e3031
2008
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1
1
-
-
-
-
-
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2
-
4
-
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2
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2
2
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2
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695542
Zhang
Development of a fluorescent s ...
Bos taurus
Anal. Biochem.
379
80-85
2008
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1
-
-
-
-
-
-
-
-
-
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1
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-
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-
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1
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1
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1
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1
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1
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-
-
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-
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-
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1
-
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1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
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697469
Feng
Isolation and characterization ...
Mesobuthus martensii
Comp. Biochem. Physiol. C
148
250-257
2008
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-
-
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1
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4
-
-
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2
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2
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-
1
-
-
-
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1
1
2
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1
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-
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-
-
-
-
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1
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4
-
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2
-
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1
-
-
-
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1
1
2
-
-
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1
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698133
Chen
Novel products in hyaluronan d ...
Bos taurus
Glycoconj. J.
26
559-566
2008
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1
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-
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2
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4
-
1
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1
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1
-
-
-
-
-
-
-
-
-
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-
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-
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-
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2
-
-
4
-
1
-
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1
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-
-
-
-
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699233
Kaessler
Indole carboxamides inhibit bo ...
Bos taurus
J. Enzyme Inhib. Med. Chem.
23
719-727
2008
4
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4
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1
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-
-
-
-
1
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1
-
1
-
-
-
1
-
-
-
-
-
4
4
-
-
-
-
-
-
4
4
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
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1
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699474
Bralley
Inhibition of hyaluronidase ac ...
Bos taurus
J. Med. Food
11
307-312
2008
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1
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1
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-
-
1
-
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1
-
1
-
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-
1
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-
-
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-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
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699963
Deschrevel
Chain-length dependence of the ...
Bos taurus
Matrix Biol.
27
475-486
2008
-
-
-
-
-
-
-
1
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-
-
-
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2
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-
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-
-
2
-
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1
-
1
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-
-
1
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
1
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-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
700874
Volfova
Hyaluronidase of bloodsucking ...
Bos taurus, Chrysops viduatus, Ctenocephalides felis, Culex quinquefasciatus, Culicoides kibunensis, Eusimulium latipes, Odagmia ornata, Phlebotomus papatasi
PLoS Negl. Trop. Dis.
2
e294
2008
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1
-
-
1
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-
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7
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34
-
-
-
-
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8
2
-
14
1
7
-
-
-
7
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
7
-
-
-
-
-
-
8
2
-
14
1
7
-
-
-
7
-
-
-
-
-
-
-
-
-
701231
Stern
Hyaluronidases in cancer biolo ...
Homo sapiens
Semin. Cancer Biol.
18
275-280
2008
-
2
-
-
-
-
-
-
-
-
-
-
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1
-
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-
-
-
-
-
-
1
-
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-
-
-
-
-
-
-
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-
-
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2
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-
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-
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-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701325
Magalhaes
A hyaluronidase from Potamotry ...
Potamotrygon motoro
Toxicon
51
1060-1067
2008
-
-
-
-
-
-
4
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
1
1
2
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
1
-
-
-
-
1
-
-
-
-
1
1
2
-
2
-
2
-
-
-
-
-
-
-
-
-
678292
Chao
Structure of human hyaluronida ...
Homo sapiens
Biochemistry
46
6911-6920
2007
-
-
1
1
-
-
-
-
-
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2
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-
3
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680043
Hofinger
Recombinant human hyaluronidas ...
Homo sapiens
Glycobiology
17
444-453
2007
-
-
1
-
-
-
7
-
1
-
2
-
-
4
-
1
1
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
5
-
-
1
-
-
-
-
5
7
-
-
1
-
2
-
-
-
1
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
680397
Hosoe
Lepidepyrone, a new gamma-pyro ...
Bos taurus
J. Antibiot.
60
388-390
2007
-
-
-
-
-
-
1
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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681684
Vigdorovich
Ability of hyaluronidase 2 to ...
Homo sapiens
J. Virol.
81
3124-3129
2007
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1
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-
-
-
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-
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-
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3
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
682896
Cibulkova
Preliminary characterization o ...
Sus scrofa
Theriogenology
68
1047-1054
2007
-
-
-
-
-
-
-
-
-
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4
-
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1
-
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1
-
-
3
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
1
-
3
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
682929
da Silveira
Hyaluronidases in Loxosceles i ...
Loxosceles intermedia
Toxicon
49
758-768
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
682931
Nagaraju
Purification and properties of ...
Hippasa partita
Toxicon
50
383-393
2007
1
-
-
-
-
-
3
-
-
3
1
-
-
1
-
-
1
-
-
1
2
-
2
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
-
3
1
-
-
-
-
1
-
1
2
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
664596
Stern
Hyaluronidases: their genomics ...
Apis mellifera, Bos taurus, Homo sapiens, Mus musculus
Chem. Rev.
106
818-839
2006
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666984
Morey
Purification and properties of ...
Palamneus gravimanus
Toxicon
47
188-195
2006
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677943
Matalon
Hyaluronidase increases the bi ...
Bos taurus
Biochem. Biophys. Res. Commun.
350
783-787
2006
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678378
Christopoulos
Hyaluronidase and CD44 hyaluro ...
Homo sapiens
Biochim. Biophys. Acta
1760
1039-1045
2006
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678640
Spickenreither
Novel 6-O-acylated vitamin C d ...
Bos taurus
Bioorg. Med. Chem. Lett.
16
5313-5316
2006
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679019
Lokeshwar
HYAL1-v1, an alternatively spl ...
Homo sapiens
Cancer Res.
66
11219-11227
2006
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679226
Kobayashi
A hyaluronidase supercatalyst ...
Bos taurus, Ovis aries
Chemistry
12
5962-5971
2006
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681742
Asteriou
Inhibition of hyaluronan hydro ...
Bos taurus
Matrix Biol.
25
166-174
2006
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664151
Girish
A low molecular weight isoform ...
Naja naja
Biochemistry (Moscow)
70
708-712
2005
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664152
Girish
Inhibition of Naja naja venom ...
Naja naja
Biochemistry (Moscow)
70
948-952
2005
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664710
Gatphayak
-
Molecular characterization of ...
Sus scrofa
Cytogenet. Genome Res.
109
535
2005
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665038
Ng
Cloning and molecular characte ...
Synanceia horrida
Gene
346
71-81
2005
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666192
Vigdorovich
Expression and characterizatio ...
jaagsiekte sheep retrovirus
J. Virol.
79
79-86
2005
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666687
Salmen
Sulphated oligosaccharides as ...
Apis mellifera, Bos taurus
Planta Med.
71
727-732
2005
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664241
Girish
Isolation and characterization ...
Naja naja
Biochimie
86
193-202
2004
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664405
Chowpongpang
Cloning and characterization o ...
Bos taurus
Biotechnol. Lett.
26
1247-1252
2004
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649321
Takahashi
A fluorometric Morgan-Elson me ...
Bos taurus, Homo sapiens, Oryctolagus cuniculus
Anal. Biochem.
322
257-263
2003
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650273
Maksimenko
-
Role of glycosaminoglycan micr ...
Bos taurus
Biochemistry (Moscow)
68
1055-1062
2003
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650500
Ling
Effects of iridoids on lipoxyg ...
Bos taurus
Biol. Pharm. Bull.
26
352-356
2003
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2
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1
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650509
Maingonnat
Hyaluronidase in sera of tumou ...
Mus musculus
Biomarkers
8
333-338
2003
-
1
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1
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1
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1
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652643
Okorukwu
Effects of ascorbic acid and a ...
Bos taurus
J. Enzyme Inhib. Med. Chem.
18
377-382
2003
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4
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2
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1
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649319
Ikegami-Kawai
Microanalysis of hyaluronan ol ...
Bos taurus
Anal. Biochem.
311
157-165
2002
-
-
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-
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1
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4
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1
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1
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1
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1
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649735
Nakatani
Monte Carlo simulation of hyal ...
Bos taurus
Biochem. J.
365
701-705
2002
-
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2
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2
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3
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651538
Rahmanian
Testicular hyaluronidase induc ...
Mus musculus
Int. J. Cancer
97
601-607
2002
-
-
-
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1
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1
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2
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5
-
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3
-
1
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1
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651601
Li
Importance of glycosylation an ...
Macaca sp.
J. Androl.
23
211-219
2002
-
-
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2
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2
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1
1
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2
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1
1
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2
1
1
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1
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2
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2
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1
1
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1
1
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2
-
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2
1
1
-
-
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1
-
-
1
-
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-
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-
-
652294
Lokeshwar
Regulation of hyaluronidase ac ...
Homo sapiens
J. Biol. Chem.
277
33654-33663
2002
-
1
1
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3
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3
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8
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6
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1
1
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3
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8
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6
-
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653211
Girish
Snake venom hyaluronidase: an ...
Bothrops asper, Crotalus atrox, Daboia russelii, Echis carinatus, Echis carinatus sochureki, Echis pyramidum leakeyi, Gloydius blomhoffii, Naja kaouthia, Naja melanoleuca, Naja naja, Naja sputatrix, Protobothrops elegans, Protobothrops flavoviridis, Protobothrops mucrosquamatus, Vipera elegans
Mol. Cell. Biochem.
240
105-110
2002
-
-
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15
15
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15
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-
15
15
-
30
15
15
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15
-
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15
15
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-
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15
15
-
30
15
15
-
-
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15
-
-
-
-
-
-
-
-
-
649310
Asteriou
An improved assay for the N-Ac ...
Bos taurus
Anal. Biochem.
293
53-59
2001
-
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1
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1
1
-
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1
-
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1
-
-
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-
-
-
-
-
-
649440
Kudo
Characterization of hyaluronid ...
Agkistrodon contortrix contortrix
Arch. Biochem. Biophys.
386
154-162
2001
-
-
-
-
-
-
-
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1
-
2
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6
-
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1
1
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1
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2
1
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1
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1
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2
1
-
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-
-
-
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-
-
-
-
649571
Comtesse
Identification of a nuclear va ...
Homo sapiens
Biochem. Biophys. Res. Commun.
283
634-640
2001
-
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1
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4
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2
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4
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1
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14
-
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1
1
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1
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4
-
2
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1
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14
-
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1
1
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Xenopus kidney hyaluronidase-1 ...
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Crystal structure of hyaluroni ...
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Toida
Inhibition of hyaluronidase by ...
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Krishnapillai
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Schwartz
Human vitreous hyaluronidase: ...
Homo sapiens
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171397
Thaler
Biochemical characterization o ...
Mus musculus
Biochemistry
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1995
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171398
Long-Rowe
Characteristics of hyaluronida ...
Chrysaora quinquecirrha
Toxicon
32
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1994
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Takagaki
Characterization of hydrolysis ...
Bos taurus
Biochemistry
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6503-6507
1994
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Afify
Purification and characterizat ...
Homo sapiens
Arch. Biochem. Biophys.
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Poh
Purification and partial chara ...
Synanceia horrida
Comp. Biochem. Physiol. B
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159-163
1992
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171403
Sting
Isolation and characterization ...
Streptococcus dysgalactiae
Zentralbl. Bakteriol.
272
276-282
1990
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171404
Ramanaiah
Isolation end characterization ...
Heterometrus fulvipes
Biochem. Int.
20
301-310
1990
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Hayashi
Study on the degradation of gl ...
Canis lupus familiaris
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1978
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171406
Anand
Distribution of beta-N-acetylg ...
Bubalus sp., Capra hircus
Hoppe-Seyler's Z. Physiol. Chem.
358
685-688
1977
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171408
Morton
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Purification and properties of ...
Ovis aries aries
Biochem. Soc. Trans.
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385
1973
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171409
Weissmann
The transglycosylative action ...
Bos taurus
J. Biol. Chem.
216
783-794
1955
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171410
Meyer
Hyaluronidases ...
Bos taurus, Cavia porcellus, Homo sapiens, Ovis aries aries, Sus scrofa
Adv. Enzymol. Relat. Subj. Biochem.
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1952
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