Literature summary for 3.2.1.26 extracted from

Hothorn, M.; Van den Ende, W.; Lammens, W.; Rybin, V.; Scheffzek, K.
Structural insights into the pH-controlled targeting of plant cell-wall invertase by a specific inhibitor protein (2010), Proc. Natl. Acad. Sci. USA, 107, 17427-17432.

Crystallization (Commentary)

Crystallization (Comment)	Organism
2.6 A crystal structure of cell-wall invertase 1 in complex with a protein inhibitor, cell-wall inhibitor of beta-fructosidase, from tobacco. The structure recognizes a small amino acid motif in the inhibitor that directly targets the invertase active site. The activity of INV1 and its interaction with inhibitor are strictly pH-dependent with a maximum at about pH 4.5. At this pH, isothermal titration calorimetry reveals that the inhibitor tightly binds its target with nanomolar affinity. Cell wall inhibitor of beta-fructosidase competes with sucrose for the same binding site	Arabidopsis thaliana

Crystallization (Comment)

Organism

2.6 A crystal structure of cell-wall invertase 1 in complex with a protein inhibitor, cell-wall inhibitor of beta-fructosidase, from tobacco. The structure recognizes a small amino acid motif in the inhibitor that directly targets the invertase active site. The activity of INV1 and its interaction with inhibitor are strictly pH-dependent with a maximum at about pH 4.5. At this pH, isothermal titration calorimetry reveals that the inhibitor tightly binds its target with nanomolar affinity. Cell wall inhibitor of beta-fructosidase competes with sucrose for the same binding site

Arabidopsis thaliana

Inhibitors

Inhibitors	Comment	Organism	Structure
cellwall inhibitor of beta-fructosidase	2.6 A crystal structure of cell-wall invertase 1 in complex with protein inhibitor, cell-wall inhibitor of beta-fructosidase, from tobacco. The structure recognizes a small amino acid motif in the inhibitor that directly targets the invertase active site. The activity of INV1 and its interaction with inhibitor are strictly pH-dependent with a maximum at about pH 4.5. At this pH, isothermal titration calorimetry reveals that the inhibitor tightly binds its target with nanomolar affinity	Arabidopsis thaliana

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q43866	-	-

Synonyms

Synonyms	Comment	Organism
cwINV1	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)