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Literature summary for 3.2.1.24 extracted from

  • Schutzbach, J.S.; Forsee, W.T.
    Calcium ion activation of rabbit liver alpha 1,2-mannosidase (1990), J. Biol. Chem., 265, 2546-2549.
    View publication on PubMed
Search for more literature for 3.2.1.24

Inhibitors

Inhibitors Comment Organism Structure
1-deoxymannojirimycin mannose analog, in vivo and in vitro; reversible (not by Ca2+) Oryctolagus cuniculus
Co2+
-
 Oryctolagus cuniculus
Mn2+
-
 Oryctolagus cuniculus
additional information no inhibition by Mg2+ Oryctolagus cuniculus
Tris in vivo and in vitro Oryctolagus cuniculus
Zn2+ reversible by Ca2+ Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.6
-
 methyl-2-O-alpha-D-mannopyranosyl-alpha-D-mannopyranoside 37°C, pH 6.0 Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Oryctolagus cuniculus 16020
-
microsome
-
 Oryctolagus cuniculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requirement Oryctolagus cuniculus
Ca2+ mechanism Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Man9GlcNAc2-[protein] + 4 H2O = Man5GlcNAc2-[protein] + 4 beta-D-mannopyranose mechanism: ordered equilibrium Oryctolagus cuniculus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methyl-2-O-alpha-D-mannopyranosyl-alpha-D-mannopyranoside + H2O
-
 Oryctolagus cuniculus ? + D-mannose
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 6
-
 Oryctolagus cuniculus