Any feedback?
Literature summary for 3.2.1.24 extracted from
- Neutral alpha-mannosidase activity in human serum (1976), Biochim. Biophys. Acta, 445, 398-405.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | 10-30% inhibition for acid alpha-mannosidase | Homo sapiens |  |
| methyl-alpha-D-mannopyranoside | 40-50% inhibition of acid alpha-mannosidase, neutral alpha-mannosidase not affected | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | 2-3fold increase of activity for neutral alpha-mannosidases | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
2 isoforms of neutral alpha-mannosidase | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl-alpha-D-mannopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + alpha-D-mannopyranose | - |
? | |
| methyl-alpha-D-mannopyranoside + H2O | - |
Homo sapiens | alpha-D-mannopyranose + methanol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acid alpha-mannosidase | - |
Homo sapiens |
| alpha-mannosidase C | - |
Homo sapiens |
| neutral alpha-mannosidase | - |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
10-20% loss of activity for acid alpha-mannosidase, 60-80% inhibition for neutral alpha-mannosidases | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 6.4 | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
