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Literature summary for 3.2.1.23 extracted from

  • Maier, A.B.; Westendorp, R.G.; VAN Heemst, D.
    beta-Galactosidase activity as a biomarker of replicative senescence during the course of human fibroblast cultures (2007), Ann. N. Y. Acad. Sci., 1100, 323-332.
    View publication on PubMed
Search for more literature for 3.2.1.23

Application

Application Comment Organism
analysis the enzyme is a reliable marker for the course of replicative cell senescence Homo sapiens
diagnostics the enzyme is a reliable marker for the course of replicative cell senescence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme activity is correlated with the senescence of cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast low activity during exponential growth phase, but increasing activity during decreasing culture growth and decreased mitotic activity Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 in vivo enzyme activity in different fibroblast lines, cells in different growth stages, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-bromo-4-chloro-3-indolyl-beta-D-galactoside + H2O
-
 Homo sapiens 5-bromo-4-chloroindol + beta-D-galactose
-
 ?
additional information the enzyme activity is correlated with the senescence of cells, overview Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Homo sapiens