Application | Comment | Organism |
---|---|---|
medicine | therapeutic target for type II diabetes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-butyldeoxynojirimycin | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.076 | - |
4-Methylumbelliferyl-alpha-D-glucopyranoside | - |
Homo sapiens | |
0.166 | - |
resorufin alpha-D-glucopyranoside | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl-alpha-D-glucopyranoside + H2O | assay at room temperature, 10 min incubation, 7.4 nM enzyme concentration | Homo sapiens | 4-methylumbelliferone + alpha-D-glucose | - |
? | |
resorufin alpha-D-glucopyranoside + H2O | assay at room temperature, 10 min incubation, 7.4 nM enzyme concentration | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-glucosidase | - |
Homo sapiens |
GAA | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
- |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0068 | - |
resorufin alpha-D-glucopyranoside as substrate | Homo sapiens | N-butyldeoxynojirimycin | |
0.0092 | - |
4-methylumbelliferyl-alpha-D-glucopyranoside as substrate | Homo sapiens | N-butyldeoxynojirimycin |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme mutations cause accumulation of glycogen in lysosomes, resulting in Pompe disease | Homo sapiens |