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Literature summary for 3.2.1.20 extracted from

  • Lee, S.S.; Lin, H.C.; Chen, C.K.
    Acylated flavonol monorhamnosides, alpha-glucosidase inhibitors, from Machilus philippinensis (2008), Phytochemistry, 69, 2347-2353.
    View publication on PubMed
Search for more literature for 3.2.1.20

Application

Application Comment Organism
medicine inhibitors may serve as lead to develop drugs for treatment of type 2 diabetes Geobacillus stearothermophilus

Inhibitors

Inhibitors Comment Organism Structure
3-O-alpha-L-(3'',4''-di-(Z)-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
acarbose
-
 Geobacillus stearothermophilus
kaempferol 3-O-alpha-L-(2'',4''-di-(E)-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
kaempferol 3-O-alpha-L-(2'',4''-di-(Z)-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
kaempferol 3-O-alpha-L-(2''-(Z),4''-(E)-di-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
kaempferol 3-O-alpha-L-(3'',4''-di-(E)-p-coumaroyl)-rhamnopyranoside 3'',4''-di-Ep-coumaroic acid ester, acylated flavonol monorhamnoside, alpha-glucosidase inhibitor, from Machilus philippinensis Geobacillus stearothermophilus
kaempferol 3-O-alpha-L-(3'',4''-di-(Z)-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
kaempferol 3-O-alpha-L-(3''-(E),4''-(Z)-di-p-coumaroyl)-rhamnopyranoside 3''-(E),4''-(Z)-di-p-coumaroic acid ester, acylated flavonol monorhamnoside, alpha-glucosidase inhibitor, from Machilus philippinensis Geobacillus stearothermophilus
kaempferol 3-O-alpha-L-(3''-(Z),4''-(E)-di-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
kaempferol 3-O-rhamnopyranoside
-
 Geobacillus stearothermophilus
kaempferol-3-O-rhamnopyranoside
-
 Geobacillus stearothermophilus
luteolin
-
 Geobacillus stearothermophilus
quercetin 3-O-alpha-L-(3''-(Z),4''-(E)-di-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
quercetin 3-O-rhamnopyranoside
-
 Geobacillus stearothermophilus
quercetin-3-O-rhamnopyranoside
-
 Geobacillus stearothermophilus

Organism

Organism UniProt Comment Textmining
Geobacillus stearothermophilus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl alpha-D-glucopyranoside + H2O
-
 Geobacillus stearothermophilus 4-nitrophenol + alpha-D-glucopyranose
-
 ?

Synonyms

Synonyms Comment Organism
alpha-glucosidase
-
 Geobacillus stearothermophilus
alpha-glucosidase type IV
-
 Geobacillus stearothermophilus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 IC50 value for a mixture of kaempferol-3-O-alpha-L-(3'',4''-di-(E)-pcoumaroyl)-rhamnopyranosidekaempferol-3-O-alpha-L-rhamnopyranoside, kaempferol-3-O-alpha-L-(3''-(E),4''-(Z)-di-p-coumaroyl)-rhamnopyranoside, quercetin-3-O-alpha-L-(3''-(Z),4''-(E)-di-p-coumaroyl)-rhamnopyranoside, quercetin-3-O-alpha-L-(3'',4''-di-(Z)-pcoumaroyl)-rhamnopyranoside, kaempferol-3-O-alpha-L-(3''-(Z),4''-(E)-di-pcoumaroyl)-rhamnopyranoside,kaempferol-3-O-alpha-L-(3'',4''-di-(Z)-p-coumaroyl)-rhamnopyranoside, kaempferol-3-O-alpha-L-(2'',4''-di-(E)-p-coumaroyl)-rhamnopyranoside, kaempferol-3-O-alpha-L-(2'',4''-di-(Z)-p-coumaroyl)-rhamnopyranoside, and kaempferol-3-O-alpha-L-(2''-(Z),4''-E-di-p-coumaroyl)-rhamnopyranoside: 0.00267 mM Geobacillus stearothermophilus additional information
0.000046
-
-
 Geobacillus stearothermophilus acarbose
0.001
-
-
 Geobacillus stearothermophilus kaempferol-3-O-alpha-L-(3''-(E),4''-(Z)-di-p-coumaroyl)-rhamnopyranoside
0.0061
-
-
 Geobacillus stearothermophilus kaempferol 3-O-alpha-L-(3'',4''-di-(E)-p-coumaroyl)-rhamnopyranoside
0.03305
-
-
 Geobacillus stearothermophilus quercetin-3-O-rhamnopyranoside
0.2281
-
-
 Geobacillus stearothermophilus kaempferol-3-O-rhamnopyranoside