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Literature summary for 3.2.1.20 extracted from

  • Tanabe, G.; Yoshikai, K.; Hatanaka, T.; Yamamoto, M.; Shao, Y.; Minematsu, T.; Muraoka, O.; Wang, T.; Matsuda, H.; Yoshikawa, M.
    Biological evaluation of de-O-sulfonated analogs of salacinol, the role of sulfate anion in the side chain on the alpha-glucosidase inhibitory activity (2007), Bioorg. Med. Chem., 15, 3926-3937.
    View publication on PubMed
Search for more literature for 3.2.1.20

Inhibitors

Inhibitors Comment Organism Structure
1,4-dideoxy-1,4-((R)-[(2S,3S)-2,3,4-trihydroxybutyl]episulfoniumylidene)-D-arabinitol chloride synthesis, overview Rattus norvegicus
1,4-dideoxy-1,4-((R)-[(2S,3S)-2,3,4-trihydroxybutyl]episulfoniumylidene)-D-arabinitol methyl sulfate synthesis, overview Rattus norvegicus
1,4-dideoxy-1,4-((R)-[(2S,3S)-2,4-dihydroxy-3-(sulfooxy)butyl]episulfoniumylidene)-L-arabinitol inner salt slight inhibition, synthesis, overview Rattus norvegicus
additional information no inhibition by 1,4-dideoxy-1,4-((S)-[(2S,3S)-2,3,4-trihydroxybutyl]episulfoniumylidene)-L-arabinitol methylsulfate Rattus norvegicus
salacinol i.e. 1,4-dideoxy-1,4-((S)-[(2S,3S)-2,4-dihydroxy-3-(sulfooxy)butyl]episulfoniumylidene)-D-arabinitol inner salt, isolated from aqueous extracts of roots and stems of Salacia reticulata, traditionally used for the treatment of diabetes in Sri Lanka and the south region of India Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
brush border brush border membrane vesicles Rattus norvegicus 5903
-
membrane brush border membrane vesicles Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
maltose + H2O Rattus norvegicus
-
 alpha-D-glucose + D-glucose
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
small intestine
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
maltose + H2O
-
 Rattus norvegicus alpha-D-glucose + D-glucose
-
 ?

Synonyms

Synonyms Comment Organism
maltase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0096
-
 pH 6.0, 37°C, inhibition of the maltase activity Rattus norvegicus salacinol
0.014
-
 pH 6.0, 37°C, inhibition of the maltase activity Rattus norvegicus 1,4-dideoxy-1,4-((R)-[(2S,3S)-2,3,4-trihydroxybutyl]episulfoniumylidene)-D-arabinitol chloride
0.0156
-
 pH 6.0, 37°C, inhibition of the maltase activity Rattus norvegicus 1,4-dideoxy-1,4-((R)-[(2S,3S)-2,3,4-trihydroxybutyl]episulfoniumyl-idene)-D-arabinitol methyl sulfate
1.197
-
 pH 6.0, 37°C, inhibition of the maltase activity Rattus norvegicus 1,4-dideoxy-1,4-((R)-[(2S,3S)-2,4-dihydroxy-3-(sulfooxy)butyl]episulfoniumylidene)-L-arabinitol inner salt