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Literature summary for 3.2.1.180 extracted from
- Insights into the catalytic mechanism of unsaturated glucuronyl hydrolase of Bacillus sp. GL1 (2017), J. Phys. Chem. B, 121, 931-941 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | free-energy profiles of the catalytic reaction, overview | Bacillus sp. GL1 |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-D-4-deoxy-DELTA4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O | Bacillus sp. GL1 | - |
5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus sp. GL1 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-D-4-deoxy-DELTA4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O | - |
Bacillus sp. GL1 | 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate | - |
? | |
| additional information | almost all interactions between the substrate and enzyme are related to the D-glucuronic acid unit, whereas no recognition specificity is observed for the N-acetyl-D-galactosamine unit | Bacillus sp. GL1 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UGL | - |
Bacillus sp. GL1 |
| unsaturated glucuronyl hydrolase | - |
Bacillus sp. GL1 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | the enzyme is a member of the glycoside hydrolase family 88, GH88 | Bacillus sp. GL1 |
| additional information | glycosaminoglycan degradation mechanism, combined quantum mechanical and molecular mechanical method and simulation, modelling, two pathways, detailed overview. Almost all interactions between the substrate and enzyme are related to the D-glucuronic acid unit, whereas no recognition specificity is observed for the N-acetyl-D-galactosamine unit | Bacillus sp. GL1 |
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