Literature summary for 3.2.1.18 extracted from

Lee, Y.; Youn, H.S.; Lee, J.G.; An, J.Y.; Park, K.R.; Kang, J.Y.; Ryu, Y.B.; Jin, M.S.; Park, K.H.; Eom, S.H.
Crystal structure of the catalytic domain of Clostridium perfringens neuraminidase in complex with a non-carbohydrate-based inhibitor, 2-(cyclohexylamino)ethanesulfonic acid (2017), Biochem. Biophys. Res. Commun., 486, 470-475 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21 CodonPlus (DE3) cells	Clostridium perfringens

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with 2-(cyclohexylamino)ethanesulfonic acid, hanging drop vapor diffusion method, using 20% (w/v) PEG 3350 and 0.2 M ammonium sulfate	Clostridium perfringens

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(cyclohexylamino)ethanesulfonic acid	-	Clostridium perfringens
oseltamivir	-	Clostridium perfringens
zanamivir	-	Clostridium perfringens

Organism

Organism	UniProt	Comment	Textmining
Clostridium perfringens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA column chromatography and Superdex 200 gel filtration	Clostridium perfringens

Synonyms

Synonyms	Comment	Organism
NanICD	-	Clostridium perfringens
neuraminidase	-	Clostridium perfringens

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Release 2023.1 (January 2023)