Literature summary for 3.2.1.18 extracted from

Tsurudome, M.; Ito, M.; Nishio, M.; Nakahashi, M.; Kawano, M.; Komada, H.; Nosaka, T.; Ito, Y.
Identification of domains on the fusion (F) protein trimer that influence the hemagglutinin-neuraminidase specificity of the of protein in mediating cell-cell fusion (2011), J. Virol., 85, 3153-3161.

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Protein Variants

Protein Variants	Comment	Organism
additional information	replacement of the F protein of parainfluenza virus 5 major domains, M1, M2, M3, and M4, and five minor domains, A to E, in the middle region of the PIV5 F protein with the simian virus 41, SV41, F counterparts individually or in combination. A chimera designated M(1+2), which harbored SV41 F-derived domains M1 and M2, mediates cell-cell fusion with the coexpressed SV41 hemagglutinin-neuraminidase protein, suggesting that these domains are involved in determining the hemagglutinin-neuraminidase protein specificity. Another chimera which harbors the SV41 F-derived domain B in addition to domains M1 and M2 shows increased specificity for the SV41 hemagglutinin-neuraminidase protein compared to that of M(1+2), although it is capable of mediating cell-cell fusion by itself	Mammalian orthorubulavirus 5

Organism

Organism	UniProt	Comment	Textmining
Mammalian orthorubulavirus 5	-	PIV5	-

Subunits

Subunits	Comment	Organism
trimer	four major domains, M1, M2, M3, and M4, and five minor domains, A to E, in the middle region of the PIV5 F protein are exposed on the trimer surface	Mammalian orthorubulavirus 5

Synonyms

Synonyms	Comment	Organism
neuraminidase	-	Mammalian orthorubulavirus 5

General Information

General Information	Comment	Organism
additional information	the amino terminal region of the PIV5 hemagglutinin-neuraminidase protein determines the F protein specificity in promoting cell-cell fusion	Mammalian orthorubulavirus 5
physiological function	the middle region of the HPIV2 F protein contains the site(s) that determines its specificity for the HPIV2 hemagglutinin-neuraminidase protein	Mammalian orthorubulavirus 5

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Release 2023.1 (January 2023)