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Literature summary for 3.2.1.18 extracted from

  • Baz, M.; Abed, Y.; Simon, P.; Hamelin, M.E.; Boivin, G.
    Effect of the neuraminidase mutation H274Y conferring resistance to oseltamivir on the replicative capacity and virulence of old and recent human influenza A(H1N1) viruses (2010), J. Infect. Dis., 201, 740-745.
    View publication on PubMed
Search for more literature for 3.2.1.18

Protein Variants

Protein Variants Comment Organism
H274Y the mutation confers resistance to oseltamivir, the viral fitness of the A/Brisbane/59/2007-like H274Y variant is not impaired Influenza A virus (A/Brisbane/59/2007(H1N1))

Inhibitors

Inhibitors Comment Organism Structure
A-315675
-
 Influenza A virus (A/Brisbane/59/2007(H1N1))
oseltamivir
-
 Influenza A virus (A/Brisbane/59/2007(H1N1))
peramivir
-
 Influenza A virus (A/Brisbane/59/2007(H1N1))
zanamivir
-
 Influenza A virus (A/Brisbane/59/2007(H1N1))

Organism

Organism UniProt Comment Textmining
Influenza A virus (A/Brisbane/59/2007(H1N1))
-
 H1N1, strain A/Brisbane/59/2007-like
-

Synonyms

Synonyms Comment Organism
neuraminidase
-
 Influenza A virus (A/Brisbane/59/2007(H1N1))

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000005
-
-
 Influenza A virus (A/Brisbane/59/2007(H1N1)) zanamivir
0.0000012
-
-
 Influenza A virus (A/Brisbane/59/2007(H1N1)) A-315675
0.0001135
-
-
 Influenza A virus (A/Brisbane/59/2007(H1N1)) peramivir
0.0004
-
 IC50 above 0.0004 mM Influenza A virus (A/Brisbane/59/2007(H1N1)) oseltamivir