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Literature summary for 3.2.1.18 extracted from

  • Seyrantepe, V.; Iannello, A.; Liang, F.; Kanshin, E.; Jayanth, P.; Samarani, S.; Szewczuk, M.R.; Ahmad, A.; Pshezhetsky, A.V.
    Regulation of phagocytosis in macrophages by neuraminidase 1 (2010), J. Biol. Chem., 285, 206-215.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.18

Activating Compound

Activating Compound Comment Organism Structure
cathepsin A
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Mus musculus 9986
-

Organism

Organism UniProt Comment Textmining
Mus musculus O35657
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-
macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
-
 Mus musculus 4-methylumbelliferone + N-acetylneuraminic acid
-
 ?

Synonyms

Synonyms Comment Organism
NEU1
-
 Mus musculus
neuraminidase 1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction the absence of Neu1 results in the increased sialylation of the cell surface proteins, probably affecting multiple receptors for phagocytosis. Macrophages from the Neu1-deficient mice show increased sialylation and impaired phosphorylation of FcgammaRas well as markedly reduced phosphorylation of Syk kinase in response to treatment with immunoglobulin G-opsonized beads Mus musculus
physiological function treatment of the cells with purified mouse Neu1 reduces surface sialylation and restores phagocytosis. Cell surface Neu1 activates the phagocytosis in macrophages and dendritic cells through desialylation of surface receptors, thus, contributing to their functional integrity Mus musculus