Literature summary for 3.2.1.18 extracted from

Abed, Y.; Baz, M.; Boivin, G.
A novel neuraminidase deletion mutation conferring resistance to oseltamivir in clinical influenza A/H3N2 virus (2009), J. Infect. Dis., 199, 180-183.

Search for more literature for 3.2.1.18

Protein Variants

Protein Variants	Comment	Organism
N146K/A272V/Del245-248	revertant constructed from mutant N146K/S219T/A272V/Del245-248 for analysis of resistance to oseltamivir	influenza A virus
N146K/S219T/A272V	revertant constructed from mutant N146K/S219T/A272V/Del245-248 for analysis of resistance to oseltamivir	influenza A virus
N146K/S219T/A272V/Del245-248	mutant isolated from an oseltamivir-resistant virus from an immunocompromised child. The deletion is the sole change responsible for resistance	influenza A virus
N146K/S219T/Del245-248	revertant constructed from mutant N146K/S219T/A272V/Del245-248 for analysis of resistance to oseltamivir	influenza A virus
S219T/A272V/Del245-248	revertant constructed from mutant N146K/S219T/A272V/Del245-248 for analysis of resistance to oseltamivir	influenza A virus

Inhibitors

Inhibitors	Comment	Organism	Structure
oseltamivir	-	influenza A virus
peramivir	-	influenza A virus
zanamivir	-	influenza A virus

Organism

Organism	UniProt	Comment	Textmining
influenza A virus	-	type H3N2	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O	-	influenza A virus	4-methylumbelliferol + alpha-D-N-acetylneuraminic acid	-	?

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Release 2023.1 (January 2023)