Literature summary for 3.2.1.18 extracted from

Newstead, S.L.; Potter, J.A.; Wilson, J.C.; Xu, G.; Chien, C.H.; Watts, A.G.; Withers, S.G.; Taylor, G.L.
The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates (2008), J. Biol. Chem., 283, 9080-9088.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
catalytic domain of isoform NanI, to 0.97 A resolution, and complexes with its substrate sialic acid to 0.97A resolution, with transition-state analogue 2-deoxy-2,3-dehydro-N-acetylneuraminic acid to 1.5 A resolution, and with a covalent intermediate formed using a fluorinated sialic acid analogue to 1.2 A resolution	Clostridium perfringens

Organism

Organism	UniProt	Comment	Textmining
Clostridium perfringens	Q59310	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-deoxy-2,3-dehydro-N-acetylneuraminic acid + H2O	-	Clostridium perfringens	N-acetylneuraminic acid	reaction deduced from crystal structures and confirmed by NMR study	?

Synonyms

Synonyms	Comment	Organism
NanI	-	Clostridium perfringens

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Release 2023.1 (January 2023)