Application | Comment | Organism |
---|---|---|
medicine | isoform Neu3 plays a key role in skeletal muscle differentiation by strictly modulating the ganglioside content of adjacent cells, with special regard to GM3. Induced down-regulation of NEU3, even when partial, totally inhibits cell's capability to differentiate by increasing the GM3 level above a critical point, which causes epidermal growth factor receptor inhibition and ultimately its down-regulation and an higher responsiveness of myoblasts to the apoptotic stimuli | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | isoform Neu3 plays a key role in skeletal muscle differentiation by strictly modulating the ganglioside content of adjacent cells, with special regard to GM3 | Mus musculus | - |