Literature summary for 3.2.1.18 extracted from

Yogalingam, G.; Bonten, E.J.; van de Vlekkert, D.; Hu, H.; Moshiach, S.; Connell, S.A.; dAzzo, A.
Neuraminidase 1 is a negative regulator of lysosomal exocytosis (2008), Dev. Cell, 15, 74-86.

Search for more literature for 3.2.1.18

Application

Application	Comment	Organism
medicine	in fibroblasts from patients with sialidosis, oversialylated lysosomal membrane protein Lamp-1 enhances lysosomal exocytosis. Silencing of Lamp-1 reverts this phenotype by interfering with the docking of lysosomes at the plasma membrane	Homo sapiens
medicine	in macrophages from isoform Neu1 deficient mice, a model for sialidosis, oversialylated lysosomal membrane protein Lamp-1 enhances lysosomal exocytosis. Silencing of Lamp-1 reverts this phenotype by interfering with the docking of lysosomes at the plasma membrane. In Neu1-/- mice the excessive exocytosis of serine proteases in the bone niche leads to inactivation of extracellular serpins, premature degradation of VCAM-1, and loss of bone marrow retention	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	in macrophages from isoform Neu1 deficient mice, a model for sialidosis, oversialylated lysosomal membrane protein Lamp-1 enhances lysosomal exocytosis. Silencing of Lamp-1 reverts this phenotype by interfering with the docking of lysosomes at the plasma membrane. In Neu1-/- mice the excessive exocytosis of serine proteases in the bone niche leads to inactivation of extracellular serpins, premature degradation of VCAM-1, and loss of bone marrow retention	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q99519	isoform Neu1	-
Mus musculus	O35657	isoform Neu1	-

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Release 2023.1 (January 2023)