Literature summary for 3.2.1.18 extracted from

Mitrasinovic, P.M.
On the structure-based design of novel inhibitors of H5N1 influenza A virus neuraminidase (NA) (2009), Biophys. Chem., 140, 35-38.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(3R,4R,5R)-4-acetamido-3-(1-(diaminomethylamino)-3-hydroxypropan-2-yloxy)-5-((1S)-1,2,3-trihydroxypropyl)cyclohex-1-enecarboxylic acid	obtained by structure-based design using crystal structure PDB ID 2hty and in order to exploit experimentally identified potential benefits offered by the 150-cavity adjacent to the H5N1 neuramindase active site. Inhibitor shows low binding free energy	influenza A virus
(3R,4R,5R)-4-acetamido-5-((1S)-2-carboxy-1,2-dihydroxyethyl)-3-(1-(diaminomethylamino)-3-hydroxypropan-2-yloxy)cyclohex-1-enecarboxylic acid	obtained by structure-based design using crystal structure PDB ID 2hty and in order to exploit experimentally identified potential benefits offered by the 150-cavity adjacent to the H5N1 neuramindase active site. Inhibitor shows low binding free energy	influenza A virus

Organism

Organism	UniProt	Comment	Textmining
influenza A virus	-	type H5N1	-

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Release 2023.1 (January 2023)