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Literature summary for 3.2.1.18 extracted from

  • Ryu, Y.B.; Curtis-Long, M.J.; Kim, J.H.; Jeong, S.H.; Yang, M.S.; Lee, K.W.; Lee, W.S.; Park, K.H.
    Pterocarpans and flavanones from Sophora flavescens displaying potent neuraminidase inhibition (2008), Bioorg. Med. Chem. Lett., 18, 6046-6049.
    View publication on PubMed
Search for more literature for 3.2.1.18

Inhibitors

Inhibitors Comment Organism Structure
(6aS,12aS)-6a,12a-dihydro-6H-[1,3]dioxolo[5,6][1]benzofuro[3,2-c]chromen-3-ol noncompetitive Clostridium perfringens
pterocarpin noncompetitive Clostridium perfringens

Organism

Organism UniProt Comment Textmining
Clostridium perfringens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
-
 Clostridium perfringens 4-methylumbelliferol + alpha-D-N-acetylneuraminic acid
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0017
-
 pterocarpin
-
 Clostridium perfringens
0.0021
-
 (6aS,12aS)-6a,12a-dihydro-6H-[1,3]dioxolo[5,6][1]benzofuro[3,2-c]chromen-3-ol
-
 Clostridium perfringens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0014
-
-
 Clostridium perfringens pterocarpin
0.0032
-
-
 Clostridium perfringens (6aS,12aS)-6a,12a-dihydro-6H-[1,3]dioxolo[5,6][1]benzofuro[3,2-c]chromen-3-ol