Literature summary for 3.2.1.18 extracted from

Fanzani, A.; Giuliani, R.; Colombo, F.; Rossi, S.; Stoppani, E.; Martinet, W.; Preti, A.; Marchesini, S.
The enzymatic activity of sialidase Neu2 is inversely regulated during in vitro myoblast hypertrophy and atrophy (2008), Biochem. Biophys. Res. Commun., 370, 376-381.

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Application

Application	Comment	Organism
medicine	isoform Neu2 mRNA and enzymatic activity are significantly increased in hypertrophic myofibers. Constitutive activation of AKT or Igf-1 treatment as well as treatment with vasopressin or trichostatin results in rise in Neu2 activity. Myofiber atrophy obtained by dexamethasone treatment or starvation triggers a significant loss of Neu2 activity and is paralleled by downregulation of Neu2 transcript levels	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
L6E9 cell	myoblast cell. Isoform Neu2 mRNA and enzymatic activity are significantly increased in hypertrophic myofibers. Constitutive activation of AKT or Igf-1 treatment as well as treatment with vasopressin or trichostatin results in rise in Neu2 activity. Myofiber atrophy obtained by dexamethasone treatment or starvation triggers a significant loss of Neu2 activity and is paralleled by downregulation of Neu2 transcript levels	Rattus norvegicus	-

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Release 2023.1 (January 2023)