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Literature summary for 3.2.1.18 extracted from

  • de Barros, J.F., Jr.; Sales Alviano, D.; da Silva, M.H.; Dutra Wigg, M.; Sales Alviano, C.; Schauer, R.; dos Santos Silva Couceiro, J.N.
    Characterization of sialidase from an influenza A (H3N2) virus strain: kinetic parameters and substrate specificity (2003), Intervirology, 46, 199-206.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.16
-
2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid pH 5.2 influenza A virus
0.18
-
alpha-(2-3)-sialyllactose pH 5.2 influenza A virus
0.52
-
alpha-(2-6)-sialyllactose pH 5.2 influenza A virus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates influenza A virus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
200000 240000
-
influenza A virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bovine brain gangliosides + H2O influenza A virus
-
sialic acid + ?
-
?
bovine submaxillary gland mucin + H2O influenza A virus
-
sialic acid + ?
-
?
colominic acid + H2O influenza A virus
-
sialic acid + ?
-
?
fetuin + H2O influenza A virus
-
sialic acid + ?
-
?
orosomucoid + H2O influenza A virus
-
sialic acid + ?
-
?

Organism

Organism UniProt Comment Textmining
influenza A virus
-
H3N2, strain X-31, reassorting of influenza A/Victoria/3/75 and influenza A/PR/8/34, from inoculated chicken egg allantoic fluid
-

Purification (Commentary)

Purification (Comment) Organism
from inoculated chicken egg allantoic fluid, by ultracentrifugation, gel filtration and proteolytic treatment with pronase, soluble 'head' part of the enzyme complex influenza A virus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.15
-
purified enzyme, substrate alpha-(2-6)-sialyllactose influenza A virus
2.13
-
purified enzyme, substrate alpha-(2-3)-sialyllactose influenza A virus
11.58
-
purified enzyme, substrate 2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid influenza A virus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
-
influenza A virus 4-methylumbelliferol + alpha-D-N-acetylneuraminic acid
-
?
alpha(2-3)-sialyllactose + H2O preference for alpha(2-3)-linkages influenza A virus sialic acid + lactose
-
?
alpha(2-6)-sialyllactose + H2O
-
influenza A virus sialic acid + lactose
-
?
bovine brain gangliosides + H2O
-
influenza A virus sialic acid + ?
-
?
bovine submaxillary gland mucin + H2O
-
influenza A virus sialic acid + ?
-
?
Candida albicans cells + H2O
-
influenza A virus desialylated Candida albicans cells + sialic acid
-
?
colominic acid + H2O
-
influenza A virus sialic acid + ?
-
?
fetuin + H2O
-
influenza A virus sialic acid + ?
-
?
additional information enzyme agglutinates erythrocytes from human blood influenza A virus ?
-
?
orosomucoid + H2O
-
influenza A virus sialic acid + ?
-
?

Subunits

Subunits Comment Organism
More enzyme possesses 2 distinct regions, a globular one, exposed to the exterior, and a stem portion, part of which is inserted into the virion envelope influenza A virus

Synonyms

Synonyms Comment Organism
NA
-
influenza A virus
neuraminidase
-
influenza A virus
sialidase
-
influenza A virus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at influenza A virus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
56
-
inactivation influenza A virus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.4
-
with substrate alpha-(2-6)-sialyllactose influenza A virus

pH Range

pH Minimum pH Maximum Comment Organism
4 6.8
-
influenza A virus