Literature summary for 3.2.1.176 extracted from

Rabinovich, M.L.; Melnik, M.S.; Herner, M.L.; Voznyi, Y.V.; Vasilchenko, L.G.
Predominant nonproductive substrate binding by fungal cellobiohydrolase I and implications for activity improvement (2019), Biotechnol. J., 14, e1700712 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
cellobiose	-	Trichoderma reesei

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.000074	-	4-methylumbelliferyl beta-cellopentaoside	at pH 5.0 and 10°C	Trichoderma reesei
0.00015	-	4-methylumbelliferyl beta-cellotetraoside	at pH 5.0 and 10°C	Trichoderma reesei
0.004	-	4-trifluoromethylumbelliferyl beta-cellotrioside	at pH 5.0 and 10°C	Trichoderma reesei
0.006	-	4-methylumbelliferyl beta-cellobioside	at pH 5.0 and 10°C	Trichoderma reesei
0.0073	-	4-methylumbelliferyl beta-cellotrioside	at pH 5.0 and 10°C	Trichoderma reesei
0.0125	-	4-trifluoromethylumbelliferyl beta-cellobioside	at pH 5.0 and 10°C	Trichoderma reesei

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cellulose + H2O	Trichoderma reesei	-	cellobiose + ?	-	?

Organism

Organism	UniProt	Comment	Textmining
Trichoderma reesei	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferyl beta-cellobioside + H2O	-	Trichoderma reesei	4-methylumbelliferone + cellobiose	-	?
4-methylumbelliferyl beta-cellopentaoside + H2O	-	Trichoderma reesei	4-methylumbelliferone + cellopentaose	-	?
4-methylumbelliferyl beta-cellotetraoside + H2O	-	Trichoderma reesei	4-methylumbelliferone + cellotetraose	-	?
4-methylumbelliferyl beta-cellotrioside + H2O	-	Trichoderma reesei	4-methylumbelliferone + cellotriose	-	?
4-trifluoromethylumbelliferyl beta-cellobioside + H2O	-	Trichoderma reesei	4-trifluoromethylumbelliferone + cellobiose	-	?
4-trifluoromethylumbelliferyl beta-cellotrioside + H2O	-	Trichoderma reesei	4-trifluoromethylumbelliferone + cellotriose	-	?
cellulose + H2O	-	Trichoderma reesei	cellobiose + ?	-	?

Synonyms

Synonyms	Comment	Organism
CBHI	-	Trichoderma reesei
Cel7A	-	Trichoderma reesei
cellobiohydrolase I	-	Trichoderma reesei

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.015	-	cellobiose	pH and temperature not specified in the publication	Trichoderma reesei

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Release 2023.1 (January 2023)