Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.176 extracted from

  • Olson, D.G.; Tripathi, S.A.; Giannone, R.J.; Lo, J.; Caiazza, N.C.; Hogsett, D.A.; Hettich, R.L.; Guss, A.M.; Dubrovsky, G.; Lynd, L.R.
    Deletion of the Cel48S cellulase from Clostridium thermocellum (2010), Proc. Natl. Acad. Sci. USA, 107, 17727-17732.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.176

Organism

Organism UniProt Comment Textmining
Acetivibrio thermocellus
-
-
-

Synonyms

Synonyms Comment Organism
Cel48S cellulase
-
 Acetivibrio thermocellus
Cel48Y cellulase
-
 Acetivibrio thermocellus
celS
-
 Acetivibrio thermocellus

General Information

General Information Comment Organism
malfunction family 48 glycoside hydrolases are not necessary for growth of Clostridium thermocellum on crystalline cellulose. Creation of knockout mutants for Cel48S, the most abundant cellulosome subunit. The cellulose hydrolysis rate of the S mutant strain is 60% lower than the parent strain, with the S mutant strain also exhibiting a 40% reduction in cell yield. Although most cellulolytic bacteria have one family 48 cellulase, Clostridium thermocellum has two, Cel48S and Cel48Y. Cellulose solubilization by a Cel48S and Cel48Y double knockout is essentially the same as that of the Cel48S single knockout. Solubilization of crystalline cellulose by Clostridium thermocellum can proceed to completion without expression of a family 48 cellulase Acetivibrio thermocellus