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Literature summary for 3.2.1.169 extracted from

  • Keembiyehetty, C.; Love, D.C.; Harwood, K.R.; Gavrilova, O.; Comly, M.E.; Hanover, J.A.
    Conditional knock-out reveals a requirement for O-linked N-acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis (2015), J. Biol. Chem., 290, 7097-7113 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.169

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O Mus musculus
-
 [protein]-L-serine + N-acetyl-D-glucosamine
-
 ?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O Mus musculus
-
 [protein]-L-threonine + N-acetyl-D-glucosamine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9EQQ9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-
MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fluorescein di(N-acetyl-beta-D-glucosaminide) + H2O
-
 Mus musculus fluorescein mono(N-acetyl-beta-D-glucosaminide) + N-acetyl-D-glucosamine
-
 ?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O
-
 Mus musculus [protein]-L-serine + N-acetyl-D-glucosamine
-
 ?
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H2O
-
 Mus musculus [protein]-L-threonine + N-acetyl-D-glucosamine
-
 ?

Synonyms

Synonyms Comment Organism
O-GlcNAcase
-
 Mus musculus
O-linked N-acetylglucosaminase
-
 Mus musculus
OGA
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme knockout mice show nearly complete perinatal lethality associated with low circulating glucose and low liver glycogen stores. Enzyme loss leads to defects in metabolic homeostasis culminating in obesity and insulin resistance Mus musculus