Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3aS,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol | NAG-thiazoline, inhibits also other functionally related enzymes | Homo sapiens | |
(3aS,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-propyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol | NButGT, selective O-GlcNAcase inhibitor | Homo sapiens | |
GlcNAc | - |
Homo sapiens | |
N-[(2Z,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(phenylcarbamoyl)oxy]imino]tetrahydro-2H-pyran-3-yl]acetamide | PUGNAc, inhibits also other functionally related enzymes | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.16 | - |
4-nitrophenyl N-acetyl-beta-D-glucosaminide | OGA-FL | Homo sapiens | |
0.32 | - |
4-nitrophenyl N-acetyl-beta-D-glucosaminide | OGA-NV | Homo sapiens | |
1.5 | - |
N-acetyl-beta-D-glucosamine | for OGA-FL | Homo sapiens | |
3.6 | - |
N-acetyl-beta-D-glucosamine | an inhibitor of OGA-NV | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme is responsible for removal of the O-GlcNAc post-translational modification, is being increasingly used to aid in discerning the roles played by this form of intracellular glycosylation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferol + N-acetyl-beta-D-glucosamine | - |
? | |
4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O | - |
Homo sapiens | 4-nitrophenol + N-acetyl-beta-D-glucosamine | - |
? | |
additional information | enzyme is responsible for removal of the O-GlcNAc post-translational modification, is being increasingly used to aid in discerning the roles played by this form of intracellular glycosylation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
O-GlcNAcase | two forms of O-GlcNAcase have been studied, a full-length isoform that is better characterized, and a shorter nuclear-localized variant, arising from failure to splice out one intron | Homo sapiens |
OGA-FL | full-length form of OGA | Homo sapiens |
OGA-NV | nuclear variant | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
maximum activity | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0006 | - |
(3aS,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-propyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol | OGA-FL | Homo sapiens | |
0.0015 | - |
(3aS,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-propyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol | OGA-NV | Homo sapiens |