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Literature summary for 3.2.1.167 extracted from

  • Shi, L.; Hao, Z.; Zhang, S.; Wei, M.; Lu, B.; Wang, Z.; Ji, L.
    Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway The involvement of ERK1/2 and PKC (2018), Biochem. Pharmacol., 150, 9-23 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
D-saccharic acid 1,4-lactone SAL, a beta-glucuronidase inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
baicalin + H2O Mus musculus
-
 baicalein + D-glucuronate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
baicalin + H2O
-
 Mus musculus baicalein + D-glucuronate
-
 ?

Synonyms

Synonyms Comment Organism
beta-glucuronidase
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the protective effect of baicalin (the main active compound in Scutellariae radix (Huangqin)) against aminoacetophen (APAP or paracetamol)-induced hepatotoxicity is not altered through enzyme inhibition by D-saccharic acid 1.4-lactone. SAL, a beta-glucuronidase inhibitor, strongly decreased the intestinal beta-glucuronidase activity in mice, but the baicalin-provided protection against APAP-induced cytotoxicity in L-02 cells is not altered after the application of SAL, thus protection of baicalin against APAP-induced hepatotoxicity does not require the conversion into its aglycone baicalein Mus musculus