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Literature summary for 3.2.1.163 extracted from

  • Daniel, P.F.; Evans, J.E.; De Gasperi, R.; Winchester, B.; Warren, C.D.
    A human lysosomal alpha (1-6)-mannosidase active on the branched trimannosyl core of complex glycans (1992), Glycobiology, 2, 327-336.
    View publication on PubMed
Search for more literature for 3.2.1.163

Inhibitors

Inhibitors Comment Organism Structure
swainsonine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is active on the branched trimannosyl core of complex glycans cleaving alphal-6-linked mannose residues from branched Man3Glc-NAc to form Manalphal-3Manbeta1-4GlcNAc, overview, activities of alpha-mannosidases in fibroblasts, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially by affinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is active on the branched trimannosyl core of complex glycans cleaving alphal-6-linked mannose residues from branched Man3Glc-NAc to form Manalphal-3Manbeta1-4GlcNAc, overview, activities of alpha-mannosidases in fibroblasts, overview Homo sapiens ?
-
 ?
additional information substrate specificity, the enzyme cleaves alphal-6-linked mannose residues from branched Man3Glc-NAc to form Manalphal-3Manbeta1-4GlcNAc, but shows little activity on artificial substrates 4-methylumbelliferyl alpha-mannoside and 4-nitrophenyl alpha-mannoside, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
lysosomal alpha (1-6)-mannosidase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4
-
-
 Homo sapiens