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Literature summary for 3.2.1.143 extracted from

  • Hou, Q.; Hu, X.; Sheng, X.; Liu, Y.; Liu, C.
    Theoretical study on the degradation of ADP-ribose polymer catalyzed by poly(ADP-ribose) glycohydrolase (2013), J. Mol. Graph. Model., 42, 26-31.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
reaction mechanism modelling on crystal structure PDB ID 3SIG Thermomonospora curvata

Inhibitors

Inhibitors Comment Organism Structure
adenosine diphosphate (hydroxymethyl)-pyrrolidinediol ADP-HPD Thermomonospora curvata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
poly(ADP-D-ribose)n + H2O Thermomonospora curvata
-
poly(ADP-D-ribose)n-1 + ADP-ribose
-
?

Organism

Organism UniProt Comment Textmining
Thermomonospora curvata D1AC29
-
-

Reaction

Reaction Comment Organism Reaction ID
(ADP-ribose)n + H2O = (ADP-ribose)n-1 + ADP-ribose catalytic mechanism, modelling, overview Thermomonospora curvata

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information hydrolysis of glycosidic ribose-ribose bond Thermomonospora curvata ?
-
?
poly(ADP-D-ribose)n + H2O
-
Thermomonospora curvata poly(ADP-D-ribose)n-1 + ADP-ribose
-
?

Synonyms

Synonyms Comment Organism
PARG
-
Thermomonospora curvata

General Information

General Information Comment Organism
additional information enzyme structure-function relationship, computational analysis based on the crystal structure, PDB ID 3SIG, modelling of active site structure and SN2 mechanism catalytic mechanism, overview. The oxocarbenium expected by Dea Slade is a possible transition state but not an intermediate. Thermomonospora curvata