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Literature summary for 3.2.1.143 extracted from

  • Frizzell, K.M.; Gamble, M.J.; Berrocal, J.G.; Zhang, T.; Krishnakumar, R.; Cen, Y.; Sauve, A.A.; Kraus, W.L.
    Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells (2009), J. Biol. Chem., 284, 33926-33938.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function stable knock-down of poly(ADP-ribose) polymerase PARP-1 and PARG. The majority of genes affected by the knockdown of one factor are similarly affected by the knockdown of the other factor. The most robustly regulated common genes are enriched for stress-response and metabolic functions. PARP-1 and PARG localize to the promoters of positively and negatively regulated target genes. The levels of chromatin-bound PARG at a given promoter generally correlate with the levels of PARP-1 across the subset of promoters tested. For about half of the genes tested, the binding of PARP-1 at the promoter is dependent on the binding of PARG. PARP-1 and PARG enzymatic activities are required for some, but not all, target genes Homo sapiens