Literature summary for 3.2.1.143 extracted from

Cohausz, O.; Blenn, C.; Malanga, M.; Althaus, F.R.
The roles of poly(ADP-ribose)-metabolizing enzymes in alkylation-induced cell death (2008), Cell. Mol. Life Sci., 65, 644-655.

Search for more literature for 3.2.1.143

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	inhibition of PARG in HeLa cells treated with 50 microM cell death inducing alkylating agent N-methyl-N'-nitro-N'-nitrosoguanidine leads (MNNG) increases poly(ADP-ribose) levels beyond control, untreated and MNNG-treated PARG-silenced cells show a tendency to larger amounts of long (more than 20 ADP-ribose units) polymers, and a slight increase in short and medium long polymers, however PARG-silencing has no effect on cell death, no effect on translocation of apoptosis-inducing factor (AIF) into nucleus	Homo sapiens
siRNA	small interfering RNA, down regulation of PARG to 50% 24 h after siRNA transfection, maximum of 84% inhibition after 72 compared to negative control with ineffective scrambled siRNA, siRNA produced in vitro from cDNA with 21-nucleotide sequence target in human coding region of the enzyme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human cervical carcinoma cells HeLa-S3	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa-S3 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
poly(ADP-ribose) + H2O	P32-labelled poly(ADP-ribose) produced by PARP-1 (poly(ADP-ribose) polymerase) of labelled NAD+	Homo sapiens	ADP-ribose + ADP-ribose oligomer	-	?

Synonyms

Synonyms	Comment	Organism
PARG	-	Homo sapiens
poly(ADP-ribose) glycohydrolase	-	Homo sapiens

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Release 2023.1 (January 2023)