Literature summary for 3.2.1.143 extracted from

Keil, C.; Groebe, T.; Oei, S.L.
MNNG-induced cell death is controlled by interactions between PARP-1, poly(ADP-ribose) glycohydrolase, and XRCC1 (2006), J. Biol. Chem., 281, 34394-34405.

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Application

Application	Comment	Organism
medicine	DNA repair factor XRCC1 is involved in regulating a poly(ADP-ribose)-mediated apoptotic cell death	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HeLa cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q0MQR4	-	-

Subunits

Subunits	Comment	Organism
More	the catalytic domain of poly(ADP-ribose) glycohydrolase interacts with the automodification domain of poly(ADP-ribose) polymerase. Poly(ADP-ribose) glycohydrolase also interacts with DNA repair factor XRCC1	Homo sapiens

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Release 2023.1 (January 2023)