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Literature summary for 3.2.1.143 extracted from

  • Ying, W.; Sevigny, M.B.; Chen, Y.; Swanson, R.A.
    Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death (2001), Proc. Natl. Acad. Sci. USA, 98, 12227-12232.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
gallotannin inhibition of enzyme activity. In presence of inhibitor, reduction of cell death after exposure to hydrogen peroxide, N-methyl-D-aspartate, or N-methyl-NĀ’-nitro-N-nitrosoguanidine Mus musculus
nobotanin B inhibition of enzyme activity. In presence of inhibitor, reduction of cell death after exposure to hydrogen peroxide, N-methyl-D-aspartate, or N-methyl-NĀ’-nitro-N-nitrosoguanidine Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme is a necessary component of the poly(ADP-ribose) polymerase 1 mediated cell death pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte cell culture Mus musculus
-
cell culture of neuronal cell and astrocytes Mus musculus
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neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is a necessary component of the poly(ADP-ribose) polymerase 1 mediated cell death pathway Mus musculus ?
-
 ?